Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines

López Barallobre, BlancaRodríguez Ramírez, AleixSantos, DavidAlbert Mach, JoanAriza Piquer, XavierGarcía Gómez, JordiGranell Sanvicente, Jaime Ramón2014-01-072014-01-0720111359-7345https://hdl.handle.net/2445/48695An unprecedented NH2-directed Pd(II)-catalytic carbonylation of quaternary aromatic α -amino esters to yield 6-membered 10 benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones. The steric hindrance around the amino group seems to be pivotal for the success of the process.3 p.application/pdfeng(c) López, Blanca et al., 2011Pal·ladi (Element químic)Química organometàl·licaReaccions químiquesLactamesIminesPalladiumOrganometallic chemistryChemical reactionsLactamsIminesPreparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylaminesinfo:eu-repo/semantics/article5807582014-01-07info:eu-repo/semantics/openAccess