Rubín García, MaríaVitelli Storelli, FacundoÁlvarez Álvarez, LauraMartínez-González, Miguel Ángel, 1957-Salas Salvadó, JordiCorella Piquer, DoloresHernáez Camba, ÁlvaroMartínez, J. AlfredoAlonso Gómez, Ángel M.Wärnberg, JuliaVioque, JesúsRomaguera, DoraLópez Miranda, JoséEstruch Riba, RamonTinahones, Francisco J.Serra Majem, LluísCano Ibáñez, NaomiTur, Josep AntoniMarcos Delgado, AlbaTresserra i Rimbau, AnnaPintó Sala, XavierDelgado Rodríguez, MiguelMatía Martín, PilarVidal, JosepVázquez, ClotildeDaimiel, LidiaRos Rahola, EmilioVázquez Ruiz, ZenaidaBabio, NancyBarragán, RocíoCastañer Niño, OlgaRazquin, CristinaTojal Sierra, LucasGómez Gracia, EnriqueGonzález Palacios, SandraMorey, MargaGarcía Rios, AntonioCastro-Barquero, SaraBernal López, M. RosaSantos Lozano, José ManuelRuiz Canela, MiguelCastro Salomó, AntoniPascual Castelló, Eva CristinaMoldon, VerónicaBullón Vela, VanessaSorto Sanchez, CarolinaCenoz Osinaga, Juan CarlosGutiérrez, LilianaMengual, MairaLamuela Raventós, Rosa Ma.Martín Sánchez, Vicente2024-01-302024-01-302022-10-012047-9980https://hdl.handle.net/2445/206726Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. This cross- sectional analysis involved baseline data of 6332 participants. Food polyphenol con- tent was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol-Explorer database. Multivariable-adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow-up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, −0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, −0.27 to −0.06]) and hydroxycinnamic acids (β coefficient, −0.19 [95% CI, −0.3 to −0.09]), alkylmethoxyphenols (β coefficient, −0.2 [95% CI, −0.31 to −0.1]), and methoxyphenols (β coefficient, −0.24 [95% CI, −0.34 to −0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71– 0.95]; PR, 0.82 [95% CI, 0.71– 0.95]; PR, 0.80 [95% CI, 0.70– 0.92]; and PR, 0.79 [95% CI, 0.69– 0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly as- sociated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02– 0.26]) but not with hyperuricemia.28 p.application/pdfengcc-by-nc (c) Rubín-García, M. et al., 2022http://creativecommons.org/licenses/by-nc/4.0/Malalties cardiovascularsHiperuricèmiaCardiovascular diseasesHyperuricemiainfo:eu-repo/semantics/article7265342024-01-30info:eu-repo/semantics/openAccess