Muñoz-Torrero López-Ibarra, DiegoPérez Areales, Francisco Javier2019-02-112019-02-112018https://hdl.handle.net/2445/128109Podeu consultar el llibre complet a: http://hdl.handle.net/2445/128014Alzheimer’s disease (AD) is the main neurodegenerative disorder worldwide. Its pathogenesis involves a network where various mechanisms are interconnected. This complex pathological network makes it extremely challenging to find an efficacious treatment. Herein, we give an overview on the design of the so-called multi-target-directed ligands, i.e. compounds that concurrently hit several key pathogenic factors within the network, as a realistic option to tackle AD, with a particular emphasis on some structural classes of multitarget hybrids recently developed in our group.16 p.application/pdfeng(c) Research Signpost, 2018http://creativecommons.org/publicdomain/zero/1.0/Desenvolupament de medicamentsMalaltia d'AlzheimerQuímica farmacèuticaDrug developmentAlzheimer's diseasePharmaceutical chemistryinfo:eu-repo/semantics/bookPart310893info:eu-repo/semantics/openAccess