A synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-episilicine

Amat Tusón, MercedesLlor Brunés, NúriaCheca Castaño, BegoñaMolins i Grau, EliesBosch Cartes, Joan2020-06-042020-06-042010-01-010022-3263https://hdl.handle.net/2445/164358Starting from an appropriate unsaturated phenylglycinol-derived oxazolopiperidone lactam, the synthesis of (-)-16-episilicine is reported, the key steps being a stereoselective conjugate addition, a stereoselective alkylation, and a ring-closing metathesis reaction. This represents the first enantioselective total synthesis of an alkaloid of the silicine group.12 p.application/pdfeng(c) American Chemical Society , 2010AlcaloidesLactamesSíntesi asimètricaAlkaloidsLactamsAsymmetric synthesisA synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-episilicineinfo:eu-repo/semantics/article5791632020-06-04info:eu-repo/semantics/openAccess19968261