Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/101573
Title: Rhinovirus Species and Clinical Features in Children Hospitalized with Pneumonia from Mozambique
Author: Annamalay, Alicia A.
Lanaspa, Miguel
Khoo, Siew-Kim
Madrid, Lola
Acácio, Sozinho
Zhang, Guicheng
Laing, Ingrid
Gern, James
Goldblatt, Jack
Bizzintino, Joelene
Lehmann, Deborah
Le Souef, Peter N.
Bassat Orellana, Quique
Keywords: Pneumònia
Infants
Moçambic
Pneumonia
Children
Mozambique
Issue Date: 26-Jul-2016
Publisher: John Wiley & Sons
Abstract: OBJECTIVES: To describe the prevalence of human rhinovirus (RV) species in children hospitalized with pneumonia in Manhica, Mozambique; and the associations between RV species and demographic, clinical, and laboratory features. METHODS: Nasopharyngeal aspirates were collected from children 0-10 years of age (n=277) presenting to Manhica District Hospital with clinical pneumonia. Blood samples were collected for HIV and malaria testing, blood culture and full blood counts, and a chest X-ray was performed. A panel of common respiratory viruses was investigated using two independent multiplex RT-PCR assays with primers specific for each virus and viral type. RV species and genotypes were identified by semi-nested PCR assays, sequencing and phylogenetic tree analyses. RESULTS: At least one respiratory virus was identified in 206 (74.4%) children hospitalized with clinical pneumonia. RV was the most common virus identified in both HIV-infected (17/38, 44.7%) and HIV-uninfected (74/237, 31.2%; p=0.100) children. RV-A was the most common RV species identified (47/275, 17.0%), followed by RV-C (35/275, 12.6%) and RV-B (8/275, 2.9%). Clinical presentation of the different RV species was similar and overlapping, with no particular species being associated with specific clinical features. CONCLUSIONS: RV-A and RV-C were the most common respiratory viruses identified in children hospitalised with clinical pneumonia in Manhica. Clinical presentation of RV-A and RV-C was similar and overlapping. This article is protected by copyright. All rights reserved.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1111/tmi.12743
It is part of: Tropical Medicine & International Health, 2016
Related resource: http://dx.doi.org/10.1111/tmi.12743
URI: http://hdl.handle.net/2445/101573
ISSN: 1360-2276
Appears in Collections:Articles publicats en revistes (ISGlobal)

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