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dc.contributor.authorMarques, Joana-
dc.contributor.authorValle Delgado, Juan José-
dc.contributor.authorUrbán, Patricia-
dc.contributor.authorBaró, Elisabet-
dc.contributor.authorProhens López, Rafael-
dc.contributor.authorMayor Aparicio, Alfredo Gabriel-
dc.contributor.authorCisteró, Pau-
dc.contributor.authorDelves, Michael-
dc.contributor.authorSinden, Robert E.-
dc.contributor.authorGrandfils, Christian-
dc.contributor.authorPaz, José L. de-
dc.contributor.authorGarcía Salcedo, José A.-
dc.contributor.authorFernàndez Busquets, Xavier-
dc.description.abstractThe adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.-
dc.format.extent12 p.-
dc.relation.isformatofVersió postprint del document publicat a:
dc.relation.ispartofNanomedicine: Nanotechnology, Biology, and Medicine, 2016-
dc.rightscc by (c) Marques et al., 2016-
dc.titleAdaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery-
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))

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