Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/104277
Title: Xyloglucan for the treatment of actue diarrhea: results of a randomized, controlled, open-label, parallel group, multicentre, national clinical trial
Author: Gnessi, Lucio
Bacarea, Vladimir
Marusteri Marius
Piqué i Clusella, Núria
Keywords: Diarrea
Vòmit
Dolor abdominal
Medicaments
Assaigs clínics
Diarrhea
Vomiting
Abdominal pain
Drugs
Clinical trials
Issue Date: 30-Oct-2015
Publisher: BioMed Central
Abstract: Background: There is a strong rationale for the use of agents with film-forming protective properties, like xyloglucan, for the treatment of acute diarrhea. However, few data from clinical trials are available. Methods: A randomized, controlled, open-label, parallel group, multicentre, clinical trial was performed to evaluate the efficacy and safety of xyloglucan, in comparison with diosmectite and Saccharomyces in adult patients with acute diarrhea due to different causes. Patients were randomized to receive a 3-day treatment. Symptoms (stools type, nausea, vomiting, abdominal pain and flatulence) were assessed by a self-administered ad-hoc questionnaire 1, 3, 6, 12, 24, 48 and 72 h following the first dose administration. Adverse events were also recorded. Results: A total of 150 patients (69.3 % women and 30.7 % men, mean age 47.3 ± 14.7 years) were included (n = 50 in each group). A faster onset of action was observed in the xyloglucan group compared with the diosmectite and S. bouliardii groups. At 6 h xyloglucan produced a statistically significant higher decrease in the mean number of type 6 and 7 stools compared with diosmectite (p = 0.031). Xyloglucan was the most efficient treatment in reducing the percentage of patients with nausea throughout the study period, particularly during the first hours (from 26 % at baseline to 4 % after 6 and 12 h). An important improvement of vomiting was observed in all three treatment groups. Xyloglucan was more effective than diosmectite and S. bouliardii in reducing abdominal pain, with a constant improvement observed throughout the study. The clinical evolution of flatulence followed similar patterns in the three groups, with continuous improvement of the symptom. All treatments were well tolerated, without reported adverse events. Conclusions: Xyloglucan is a fast, efficacious and safe option for the treatment of acute diarrhea.
Note: Reproducció del document publicat a: https://doi.org/10.1186/s12876-015-0386-z
It is part of: BMC Gastroenterology, 2015, vol. 15, p. 153
Related resource: https://doi.org/10.1186/s12876-015-0386-z
URI: http://hdl.handle.net/2445/104277
ISSN: 1471-230X
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

Files in This Item:
File Description SizeFormat 
655488.pdf1.1 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons