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Title: | The polymerization of Aeromonas hydrophila AH-3 O-antigen LPS: concerted action of WecP and Wzy |
Author: | Merino Montero, Susana Gonzalez, Victor Tomàs Magaña, Juan |
Keywords: | Bacteriòfags Transferases Polimerització Bacteriophages Transferases Polymerization |
Issue Date: | 10-Jul-2015 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | The repeat units of heteropolymeric O antigen are synthesized at the cytosolic side of the inner bacterial membrane via the Wzx/Wzy-dependent assembly pathway. After being translocated across the membrane by Wzx, each repeat unit is polymerized by Wzy to form a glycan chain. In this study, we demonstrate the need of the corresponding enzyme trans- ferring the initial HexNAc to undecaprenol phosphate (lipid carrier), together with the corre- sponding O-antigen polymerase (Wzy), to produce the Aeromonas hydrophila O:34- antigen. We suggest, the concerted action of WecA or P enzyme (UDP-HexNAc: polypre- nol-P HexNAc-1-P transferase) and Wzy is involved in the mechanism responsible for the A . hydrophila O-antigen polymerization. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0131905 |
It is part of: | PLoS One, 2015, vol. 10, num. 7, p. e0131905 |
URI: | http://hdl.handle.net/2445/104357 |
Related resource: | https://doi.org/10.1371/journal.pone.0131905 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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