Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/104357
Title: The polymerization of Aeromonas hydrophila AH-3 O-antigen LPS: concerted action of WecP and Wzy
Author: Merino Montero, Susana
Gonzalez, Victor.
Tomàs Magaña, Juan
Keywords: Bacteriòfags
Transferases
Polimerització
Bacteriophages
Transferases
Polymerization
Issue Date: 10-Jul-2015
Publisher: Public Library of Science (PLoS)
Abstract: The repeat units of heteropolymeric O antigen are synthesized at the cytosolic side of the inner bacterial membrane via the Wzx/Wzy-dependent assembly pathway. After being translocated across the membrane by Wzx, each repeat unit is polymerized by Wzy to form a glycan chain. In this study, we demonstrate the need of the corresponding enzyme trans- ferring the initial HexNAc to undecaprenol phosphate (lipid carrier), together with the corre- sponding O-antigen polymerase (Wzy), to produce the Aeromonas hydrophila O:34- antigen. We suggest, the concerted action of WecA or P enzyme (UDP-HexNAc: polypre- nol-P HexNAc-1-P transferase) and Wzy is involved in the mechanism responsible for the A . hydrophila O-antigen polymerization.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0131905
It is part of: PLoS One, 2015, vol. 10, num. 7, p. e0131905
Related resource: https://doi.org/10.1371/journal.pone.0131905
URI: http://hdl.handle.net/2445/104357
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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