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Title: Birth weight and adult IQ, but not anxious-depressive psychopathology, are associated with cortical surface area: a study in twins.
Author: Córdova Palomera, Aldo
Fatjó-Vilas Mestre, Mar
Falcón Falcón, Carles Maria
Bargalló Alabart, Núria​
Alemany Sierra, Silvia
Crespo-Facorro, Benedicto
Nenadic, Igor
Fañanás Saura, Lourdes
Keywords: Bessons
Escorça cerebral
Cerebral cortex
Issue Date: 18-Jun-2015
Publisher: Public Library of Science (PLoS)
Abstract: Background Previous research suggests that low birth weight (BW) induces reduced brain cortical sur- face area (SA) which would persist until at least early adulthood. Moreover, low BW has been linked to psychiatric disorders such as depression and psychological distress, and to altered neurocognitive profiles. Aims We present novel findings obtained by analysing high-resolution structural MRI scans of 48 twins; specifically, we aimed: i) to test the BW-SA association in a middle-aged adult sam- ple; and ii) to assess whether either depression/anxiety disorders or intellectual quotient (IQ) influence the BW-SA link, using a monozygotic (MZ) twin design to separate environ- mental and genetic effects. Results Both lower BW and decreased IQ were associated with smaller total and regional cortical SA in adulthood. Within a twin pair, lower BW was related to smaller total cortical and regional SA. In contrast, MZ twin differences in SA were not related to differences in either IQ or depression/anxiety disorders.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2015, vol. 10, num. 6, p. e:0129616
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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