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Title: FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Author: Slebe, Felipe
Rojo, Federico
Vinaixa Crevillent, Maria
García Rocha, Mar
Testoni, Giorgia
Guiu, Marc
Planet, Evarist
Samino, Sara
Arenas, Enrique J.
Beltran, Antoni
Rovira, Ana
Lluch, Ana
Salvatella i Giralt, Xavier
Yanes, Oscar
Albanell, Joan
Guinovart, Joan J. (Joan Josep), 1947-
Gomis i Cabré, Roger
Keywords: Càncer de mama
Biologia molecular
Factors de transcripció
Breast cancer
Molecular biology
Transcription factors
Issue Date: 5-Apr-2016
Publisher: Macmillan
Abstract: The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids.
Note: Reproducció del document publicat a:
It is part of: Nature Communications, 2016, vol. 7, num. 11199
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Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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