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Title: | FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth |
Author: | Slebe, Felipe Rojo, Federico Vinaixa Crevillent, Maria García Rocha, Mar Testoni, Giorgia Guiu, Marc Planet, Evarist Samino Gené, Sara Arenas, Enrique J. Beltran, Antoni Rovira, Ana Lluch Hernández, Ana Salvatella i Giralt, Xavier Yanes, Oscar Albanell Mestres, Joan Guinovart, Joan J. (Joan Josep), 1947- Gomis i Cabré, Roger |
Keywords: | Càncer de mama Hidrolases Biologia molecular Factors de transcripció Breast cancer Hydrolases Molecular biology Transcription factors |
Issue Date: | 5-Apr-2016 |
Publisher: | Macmillan |
Abstract: | The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1038/ncomms11199 |
It is part of: | Nature Communications, 2016, vol. 7, num. 11199 |
URI: | http://hdl.handle.net/2445/105633 |
Related resource: | http://dx.doi.org/10.1038/ncomms11199 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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