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Title: Transforming growth factor -α expression in rat experimental hepatocarcinogenesis
Author: Pérez Tomás, Ricardo E.
Mayol, X.
Culleré i Luengo, F. Xavier
Díaz Ruiz, Carmen
Domingo i Feliudabaló, Jordi
Keywords: Tumors
Cèl·lules hepàtiques
Rates (Animals de laboratori)
Factors de creixement
Càncer de fetge
Histopatologia veterinària
Liver cells
Rats as laboratory animals
Growth factors
Liver cancer
Veterinary histopathology
Issue Date: Jul-1992
Publisher: Universidad de Murcia
Abstract: Growth factors in general and transforming growth factor-alpha in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-alpha in chemically-induced hepatocarcinogenesis. Sprague- Dawley rats were subjected to different non-intensive or intensive carcinogenic treatments using diethylnitrosamine (DEN) as carcinogen and ethinyl estradiol (EE) as promoter. The livers were fixed in 2% paraformaldehyde, dehydrated in a series of ethanol solutions, embedded in paraffin and sectioned. In the preneoplastic lesions no TGF-alpha immunoreactive cells were identified, but in some hepatic tumours cell immunostained with TGF-alpha antibody were observed. These results suggest that the cells capable of expressing TGF-a constitutively may be involved in neoplastic development in vivo.
Note: Reproducció del document publicat a:
It is part of: Histology and Histopathology, 1992, vol. 7, num. 3, p. 457-462
ISSN: 0213-3911
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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