Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/105882
Title: | Transforming growth factor -α expression in rat experimental hepatocarcinogenesis |
Author: | Pérez Tomás, Ricardo E. Mayol, X. Culleré i Luengo, F. Xavier Díaz Ruiz, Carmen Domingo i Feliudabaló, Jordi |
Keywords: | Tumors Cèl·lules hepàtiques Rates (Animals de laboratori) Factors de creixement Càncer de fetge Histopatologia veterinària Tumors Liver cells Rats as laboratory animals Growth factors Liver cancer Veterinary histopathology |
Issue Date: | Jul-1992 |
Publisher: | Universidad de Murcia |
Abstract: | Growth factors in general and transforming growth factor-alpha in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-alpha in chemically-induced hepatocarcinogenesis. Sprague- Dawley rats were subjected to different non-intensive or intensive carcinogenic treatments using diethylnitrosamine (DEN) as carcinogen and ethinyl estradiol (EE) as promoter. The livers were fixed in 2% paraformaldehyde, dehydrated in a series of ethanol solutions, embedded in paraffin and sectioned. In the preneoplastic lesions no TGF-alpha immunoreactive cells were identified, but in some hepatic tumours cell immunostained with TGF-alpha antibody were observed. These results suggest that the cells capable of expressing TGF-a constitutively may be involved in neoplastic development in vivo. |
Note: | Reproducció del document publicat a: https://digitum.um.es/xmlui/handle/10201/18324 |
It is part of: | Histology and Histopathology, 1992, vol. 7, num. 3, p. 457-462 |
URI: | http://hdl.handle.net/2445/105882 |
ISSN: | 0213-3911 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
073060.pdf | 3.5 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License