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Title: Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer
Author: Bosch Cartes, Joan
Bachs, Jordi
Gómez, Antonia M.
Griera Farres, Rosa
Écija, Marta
Amat Tusón, Mercedes
Keywords: Antihistamínics
Estructura molecular
Síntesi orgànica
Molecular structure
Organic synthesis
Issue Date: 20-Jul-2012
Publisher: American Chemical Society
Abstract: Practical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.
Note: Versió postprint del document publicat a:
It is part of: Journal of Organic Chemistry, 2012, vol. 77, num. 14, p. 6340-6344
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ISSN: 0022-3263
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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