Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/108508
Title: Neural correlates of specific musical anhedonia
Author: Martínez-Molina, N.
Mas-Herrero, E.
Zatorre, R.
Rodríguez Fornells, Antoni
Marco Pallarés, Josep
Keywords: Trastorns afectius
Emocions
Música
Affective disorders
Emotions
Music
Issue Date: 2016
Publisher: National Academy of Sciences
Abstract: Although music is ubiquitous in human societies, there are some people for whom music holds no reward value despite normal perceptual ability and preserved reward-related responses in other domains. The study of these individuals with specific musical anhedonia may be crucial to understand better the neural correlates underlying musical reward. Previous neuroimaging studies have shown that musically induced pleasure may arise from the interaction between auditory cortical networks and mesolimbic reward networks. If such interaction is critical for music-induced pleasure to emerge, then those individuals who do not experience it should show alterations in the cortical-mesolimbic response. In the current study, we addressed this question using fMRI in three groups of 15 participants, each with different sensitivity to music reward. We demonstrate that the music anhedonic participants showed selective reduction of activity for music in the nucleus accumbens (NAcc), but normal activation levels for a monetary gambling task. Furthermore, this group also exhibited decreased functional connectivity between the right auditory cortex and ventral striatum (including the NAcc). In contrast, individuals with greater than average response to music showed enhanced connectivity between these structures. Thus, our results suggest that specific musical anhedonia may be associated with a reduction in the interplay between the auditory cortex and the subcortical reward network, indicating a pivotal role of this interaction for the enjoyment of music.
Note: Versió postprint del document publicat a: https://doi.org/10.1073/pnas.1611211113
It is part of: Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2016, vol. 113, num. 46, p. E7337-E7345
Related resource: https://doi.org/10.1073/pnas.1611211113
URI: http://hdl.handle.net/2445/108508
ISSN: 0027-8424
Appears in Collections:Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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