Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/109264
Title: Fat Redistribution Syndromes Associated with HIV-1 Infection and Combination Antiretroviral Therapy
Author: Domingo, Pere (Domingo Pedrol)
Estrada, Vicente
Lopez-Aldeguer, Jose
Villarroya i Gombau, Francesc
Martínez Chamorro, Esteban José
Keywords: Infeccions per VIH
Medicaments antivírics
Síndrome de lipodistròfia associada a VIH
Cirurgia plàstica
HIV infections
Antiviral agents
HIV-associated lipodystrophy syndrome
Plastic surgery
Issue Date: 1-Jun-2012
Publisher: Permanyer
Abstract: More than 15 years after the introduction of highly active antiretroviral therapy, HIV/HAART-associated lipodystrophy syndrome still shadows the indisputable efficacy of antiretroviral therapy. Several issues related to this complication (prevalence, diagnosis, pathogenesis, prevention, or clinical management) have not been completely clarified. However, in the last years, substantial progress has been made in elucidating some of these basic aspects. This includes a better knowledge of the pathogenic mechanisms underlying HIV/HAART-associated lipodystrophy syndrome such as genetic host determinants, the impact of HIV infection per se, as well as the contribution of antiretroviral therapy. In regard to treatment, we have learned that certain drugs are especially prone to cause HIV/HAART-associated lipodystrophy syndrome (i.e. thymidine analogues). Pharmacological interventions to treat this condition have yielded mostly disappointing results, and the only intervention which offers an immediate aesthetical improvement for patients with HIV/HAART-associated lipodystrophy syndrome is plastic surgery. Even under the most favorable conditions (ideal host genetic make-up, and the timely initiation of HIV therapy with less toxic drugs), current data show that HIV/HAART-associated lipodystrophy syndrome is a complication of HIV infection and/or antiretroviral treatment that we are unable to avoid. In the context of HIV-1-infected patients under long-term antiretroviral therapy, fat toxicity is still the dark side of the rainbow.
Note: Reproducció del document publicat a:
It is part of: AIDS Reviews, 2012, vol. 14, num. 2, p. 112-123
URI: http://hdl.handle.net/2445/109264
ISSN: 1139-6121
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Medicina)

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