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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/110393
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dc.contributor.authorCalderón i Almendro, Raquel-
dc.contributor.authorMercadal, Nerea-
dc.contributor.authorAbad Saiz, José Luis-
dc.contributor.authorAriza Piquer, Xavier-
dc.contributor.authorDelgado Cirilo, Antonio-
dc.contributor.authorGarcía Gómez, Jordi-
dc.contributor.authorRodríguez Ramírez, Aleix-
dc.contributor.authorFabriàs Domingo, Gemma-
dc.date.accessioned2017-05-03T13:40:20Z-
dc.date.available2018-04-23T22:01:15Z-
dc.date.issued2017-04-23-
dc.identifier.issn0009-3084-
dc.identifier.urihttp://hdl.handle.net/2445/110393-
dc.description.abstractThe dicyclohexylborane-mediated addition of allene 1 to (E)-2-tridecenal affords a quaternary protected 2-amino-2-vinyl-1,3-diol in good yield as a single diastereomer. This compound is readily transformed into the four stereoisomers of the quaternary (E)-2-vinyl analogs of sphingosine. The metabolic fate and the effect of these compounds on the basal sphingolipid metabolism in human A549 lung adenocarcinoma cells has been studied, together with the ceramide analog of the most relevant vinylsphingosine derivative.-
dc.format.extent8 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.chemphyslip.2017.04.008-
dc.relation.ispartofChemistry and Physics of Lipids, 2017, vol. 205, p. 34-41-
dc.relation.urihttps://doi.org/10.1016/j.chemphyslip.2017.04.008-
dc.rightscc-by-nc-nd (c) Elsevier B.V., 2017-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es-
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)-
dc.subject.classificationEsfingolípids-
dc.subject.classificationSíntesi orgànica-
dc.subject.classificationEstereoquímica-
dc.subject.classificationEnzimologia-
dc.subject.otherSphingolipids-
dc.subject.otherOrganic synthesis-
dc.subject.otherStereochemistry-
dc.subject.otherEnzymology-
dc.titleStereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec671168-
dc.date.updated2017-05-03T13:40:21Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid28445710-
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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