Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/110768
Title: Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety
Author: Chaccour, Carlos
Hammann, Felix
Rabinovich, N. Regina
Keywords: Malària
Medicina tropical
Farmacocinètica
Malaria
Tropical medicine
Pharmacokinetics
Issue Date: 24-Apr-2017
Publisher: Biomed Central
Abstract: Ivermectin is an endectocide that has been used broadly in single dose community campaigns for the control of onchocerciasis and lymphatic filariasis for more than 30 years. There is now interest in the potential use of ivermectin regimens to reduce malaria transmission, envisaged as community-wide campaigns tailored to transmission patterns and as complement of the local vector control programme. The development of new ivermectin regimens or other novel endectocides will require integrated development of the drug in the context of traditional entomological tools and endpoints. This document examines the main pharmacokinetic and pharmacodynamic parameters of the medicine and their potential influence on its vector control efficacy and safety at population level. This information could be valuable for trial design and clinical development into regulatory and policy pathways.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1186/s12936-017-1801-4
It is part of: Malaria Journal, 2017, vol. 16, num. 1, p. 161
Related resource: http://dx.doi.org/10.1186/s12936-017-1801-4
URI: http://hdl.handle.net/2445/110768
ISSN: 1475-2875
Appears in Collections:Articles publicats en revistes (ISGlobal)

Files in This Item:
File Description SizeFormat 
chaccour2017_2514.pdf1.2 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons