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Title: In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development
Author: Azagra, Alba
Román González, Lidia
Collazo, Olga
Rodríguez-Ubreva, Javier
Yébenes, Virginia G. de
Barneda-Zahonero, Bruna
Rodríguez, Jairo
Castro de Moura, Manuel
Grego-Bessa, Joaquim
Fernández-Duran, Irene
Islam, Abul B.M.M.K.
Esteller, Manel
Ramiro, Almudena R.
Ballestar Tarín, Esteban
Parra Bola, Mª Isabel
Keywords: Cèl·lules B
B cells
Issue Date: Nov-2016
Publisher: Rockefeller University Press
Abstract: Class IIa histone deacetylase (HDAC) subfamily members are tissue-specific gene repressors with crucial roles in development and differentiation processes. A prominent example is HDAC7, a class IIa HDAC that shows a lymphoid-specific expression pattern within the hematopoietic system. In this study, we explored its potential role in B cell development by generating a conditional knockout mouse model. Our study demonstrates for the first time that HDAC7 deletion dramatically blocks early B cell development and gives rise to a severe lymphopenia in peripheral organs, while also leading to pro-B cell lineage promiscuity. We find that HDAC7 represses myeloid and T lymphocyte genes in B cell progenitors through interaction with myocyte enhancer factor 2C (MEFC2). In B cell progenitors, HDAC7 is recruited to promoters and enhancers of target genes, and its absence leads to increased enrichment of histone active marks. Our results prove that HDAC7 is a bona fide transcriptional repressor essential for B cell development.
Note: Reproducció del document publicat a:
It is part of: Journal of Experimental Medicine, 2016, vol. 213, num. 12, p. 2591-2601
Related resource:
ISSN: 0022-1007
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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