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http://hdl.handle.net/2445/112005
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DC Field | Value | Language |
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dc.contributor.author | Pinazo, Maria-Jesus | - |
dc.contributor.author | Posada, Elizabeth | - |
dc.contributor.author | Izquierdo Lázaro, Luis | - |
dc.contributor.author | Tàssies Penella, María Dolores | - |
dc.contributor.author | Ferreira Marques, Alexandre | - |
dc.contributor.author | Lazzari, Elisa de | - |
dc.contributor.author | Aldasoro, Edelweiss | - |
dc.contributor.author | Muñoz, José | - |
dc.contributor.author | Abras Feliu, Alba | - |
dc.contributor.author | Tebar, Silvia | - |
dc.contributor.author | Gállego Culleré, M. (Montserrat) | - |
dc.contributor.author | Almeida, Igor Correia de | - |
dc.contributor.author | Reverter Calatayud, Juan Carlos | - |
dc.contributor.author | Gascón i Brustenga, Joaquim | - |
dc.date.accessioned | 2017-06-06T11:07:18Z | - |
dc.date.available | 2017-06-06T11:07:18Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1935-2735 | - |
dc.identifier.uri | http://hdl.handle.net/2445/112005 | - |
dc.description.abstract | Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from Chagas disease-endemic areas were classified in two groups: G1, with T.cruzi infection (n = 56); G2, healthy individuals (n = 43). Twenty-four hemostasis factors were measured at baseline. G1 patients treated with benznidazole were followed for 36 months, recording clinical parameters and performance of conventional serology, chemiluminescent enzyme-linked immunosorbent assay (trypomastigote-derived glycosylphosphatidylinositol-anchored mucins), quantitative polymerase chain reaction, and hemostasis tests every 6-month visits. Prothrombin fragment 1+2 (F1+2) and endogenous thrombin potential (ETP) were abnormally expressed in 77% and 50% of infected patients at baseline but returned to and remained at normal levels shortly after treatment in 76% and 96% of cases, respectively. Plasmin-antiplasmin complexes (PAP) were altered before treatment in 32% of G1 patients but normalized in 94% of cases several months after treatment. None of the patients with normal F1+2 values during follow-up had a positive qRT-PCR result, but 3/24 patients (13%) with normal ETP values did. In a percentage of chronic T. cruzi infected patients treated with benznidazole, altered coagulation markers returned into normal levels. F1+2, ETP and PAP could be useful markers for assessing sustained response to benznidazole. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pntd.0004269 | - |
dc.relation.ispartof | PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 1, p. e0004269 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pntd.0004269 | - |
dc.rights | cc-by (c) Pinazo, María Jesús et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) | - |
dc.subject.classification | Hemostàsia | - |
dc.subject.classification | Malalties parasitàries | - |
dc.subject.classification | Malaltia de Chagas | - |
dc.subject.other | Hemostasis | - |
dc.subject.other | Parasitic diseases | - |
dc.subject.other | Chagas' disease | - |
dc.title | Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 665580 | - |
dc.date.updated | 2017-06-06T11:07:18Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26727000 | - |
Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) Articles publicats en revistes (ISGlobal) |
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665580.pdf | 430 kB | Adobe PDF | View/Open |
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