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http://hdl.handle.net/2445/112016
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DC Field | Value | Language |
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dc.contributor.author | Santacana, Marti | - |
dc.contributor.author | Arias Sampériz, Bárbara | - |
dc.contributor.author | Mitjans Niubó, Marina | - |
dc.contributor.author | Bonillo, Albert | - |
dc.contributor.author | Montoro, Maria | - |
dc.contributor.author | Rosado, Silvia | - |
dc.contributor.author | Guillamat, Roser | - |
dc.contributor.author | Vallès, Vicenç | - |
dc.contributor.author | Pérez, Víctor | - |
dc.contributor.author | Forero, Carlos G. | - |
dc.contributor.author | Fullana, Miquel A. | - |
dc.date.accessioned | 2017-06-06T11:48:24Z | - |
dc.date.available | 2017-06-06T11:48:24Z | - |
dc.date.issued | 2016-06-29 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/112016 | - |
dc.description.abstract | BACKGROUND: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is well established, but a substantial proportion of patients do not respond to this treatment. Understanding which genetic and environmental factors are responsible for this differential response to treatment is a key step towards 'personalized medicine'. Based on previous research, our objective was to test whether the BDNF Val66Met polymorphism and/or childhood maltreatment are associated with response trajectories during exposure-based CBT for panic disorder (PD). METHOD: We used Growth Mixture Modeling to identify latent classes of change (response trajectories) in patients with PD (N = 97) who underwent group manualized exposure-based CBT. We conducted logistic regression to investigate the effect on these trajectories of the BDNF Val66Met polymorphism and two different types of childhood maltreatment, abuse and neglect. RESULTS: We identified two response trajectories ('high response' and 'low response'), and found that they were not significantly associated with either the genetic (BDNF Val66Met polymorphism) or childhood trauma-related variables of interest, nor with an interaction between these variables. CONCLUSIONS: We found no evidence to support an effect of the BDNF gene or childhood trauma-related variables on CBT outcome in PD. Future studies in this field may benefit from looking at other genotypes or using different (e.g. whole-genome) approaches. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0158224 | - |
dc.relation.ispartof | PLoS One, 2016, vol. 11, num. 6, p. e0158224 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0158224 | - |
dc.rights | cc-by (c) Santacana, Marti et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) | - |
dc.subject.classification | Ansietat | - |
dc.subject.classification | Trastorns de pànic | - |
dc.subject.classification | Maltractament infantil | - |
dc.subject.classification | Genètica humana | - |
dc.subject.classification | Polimorfisme genètic | - |
dc.subject.other | Anxiety | - |
dc.subject.other | Panic disorders | - |
dc.subject.other | Child abuse | - |
dc.subject.other | Human genetics | - |
dc.subject.other | Genetic polymorphisms | - |
dc.title | Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 668809 | - |
dc.date.updated | 2017-06-06T11:48:24Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27355213 | - |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) |
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668809.pdf | 563.51 kB | Adobe PDF | View/Open |
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