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Title: Circadian cycle-dependent MeCP2 and brain chromatin changes
Author: Martínez de Paz, Alexia
Vicente Sanchez Mut, Jose
Samitier Martí, Mireia
Petazzi, Paolo
Sáez, Mauricio
Szczesna, Karolina
Huertas, Dori
Esteller, Manel
Ausió, Juan
Keywords: Ritmes circadiaris
Expressió gènica
Circadian rhythms
Gene expression
Issue Date: 13-Apr-2015
Publisher: Public Library of Science (PLoS)
Abstract: Abstract Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein of the brain, very abundant especially in neurons, where it plays an important role in the regulation of gene expression. Hence it has the potential to be affected by the mammalian circadian cycle. We performed expression analyses of mice brain frontal cortices obtained at different time points and we found that the levels of MeCP2 are altered circadianly, affecting overall organization of brain chromatin and resulting in a circadian-dependent regulation of well-stablished MeCP2 target genes. Furthermore, this data suggests that alterations of MeCP2 can be responsible for the sleeping disorders arising from pathological stages, such as in autism and Rett syndrome.
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It is part of: PLoS One, 2015
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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