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http://hdl.handle.net/2445/112164
Title: | Circadian cycle-dependent MeCP2 and brain chromatin changes |
Author: | Martínez de Paz, Alexia Vicente Sanchez Mut, Jose Samitier Martí, Mireia Petazzi, Paolo Sáez, Mauricio Szczesna, Karolina Huertas, Dori Esteller, Manel Ausió, Juan |
Keywords: | Ritmes circadiaris Cromatina Expressió gènica Circadian rhythms Chromatin Gene expression |
Issue Date: | 13-Apr-2015 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Abstract Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein of the brain, very abundant especially in neurons, where it plays an important role in the regulation of gene expression. Hence it has the potential to be affected by the mammalian circadian cycle. We performed expression analyses of mice brain frontal cortices obtained at different time points and we found that the levels of MeCP2 are altered circadianly, affecting overall organization of brain chromatin and resulting in a circadian-dependent regulation of well-stablished MeCP2 target genes. Furthermore, this data suggests that alterations of MeCP2 can be responsible for the sleeping disorders arising from pathological stages, such as in autism and Rett syndrome. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0123693 |
It is part of: | PLoS One, 2015 |
URI: | http://hdl.handle.net/2445/112164 |
Related resource: | https://doi.org/10.1371/journal.pone.0123693 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Publicacions de projectes de recerca finançats per la UE |
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