Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/112425
Title: Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants
Author: Molins Monteys, Blanca
Fuentes Prior, Pablo
Adán Civera, Alfredo
Antón, Rosa
Aróstegui Gorospe, Juan Ignacio
Yagüe, Jordi
Dick, Andrew D.
Keywords: Inflamació
Malalties de la retina
Degeneració (Patologia)
Malalties de les persones grans
Inflammation
Retinal diseases
Degeneration (Pathology)
Older people diseases
Issue Date: 10-Mar-2016
Publisher: Nature Publishing Group
Abstract: Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) have been shown to be associated with an increased risk for AMD, the pathophysiological importance of the prototypical acute-phase reactant in the etiology of the disease is unknown, and data regarding the exact role of CRP in ocular inflammation are limited. In this study, we provide mechanistic insight into how CRP contributes to the development of AMD. In particular, we show that monomeric CRP (mCRP) but not the pentameric form (pCRP) upregulates IL-8 and CCL2 levels in retinal pigment epithelial cells. Further, we show that complement factor H (FH) binds mCRP to dampen its proinflammatory activity. FH from AMD patients carrying the 'risk' His402 polymorphism displays impaired binding to mCRP, and therefore proinflammatory effects of mCRP remain unrestrained.
Note: Reproducció del document publicat a: https://doi.org/10.1038/srep22889
It is part of: Scientific Reports, 2016, vol. 6, num. 22889, p. 1-12
Related resource: https://doi.org/10.1038/srep22889
URI: http://hdl.handle.net/2445/112425
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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