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Title: Mimicking the kidney: A key role in organ-on-chip development
Author: Paoli, Roberto
Samitier i Martí, Josep
Keywords: Sistema monoxip
Malalties del ronyó
Systems on a chip
Kidney diseases
Issue Date: 2016
Publisher: MDPI
Abstract: Pharmaceutical drug screening and research into diseases call for significant improvement in the effectiveness of current in vitro models. Better models would reduce the likelihood of costly failures at later drug development stages, while limiting or possibly even avoiding the use of animal models. In this regard, promising advances have recently been made by the so-called "organ-on-chip"(OOC) technology. By combining cell culture with microfluidics, biomedical researchers have started to develop microengineered models of the functional units of human organs. With the capacity to mimic physiological microenvironments and vascular perfusion, OOC devices allow the reproduction of tissue- and organ-level functions. When considering drug testing, nephrotoxicity is a major cause of attrition during pre-clinical, clinical, and post-approval stages. Renal toxicity accounts for 19% of total dropouts during phase III drug evaluation more than half the drugs abandoned because of safety concerns. Mimicking the functional unit of the kidney, namely the nephron, is therefore a crucial objective. Here we provide an extensive review of the studies focused on the development of a nephron-on-chip device.
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It is part of: Micromachines, 2016, vol. 7, num. 7, p. 126
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ISSN: 2072-666X
Appears in Collections:Articles publicats en revistes (Electrònica)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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