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Title: | Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study |
Author: | Shi, Ting McAllister, David A. O'Brien, Katherine L. Simoes, Eric A. F. Madhi, Shabir A. Gessner, Bradford D. Polack, Fernando P. Balsells, Evelyn Acácio, Sozinho Aguayo, Claudia Alassani, Issifou Moyes, Jocelyn Nymadawa, Pagbajabyn Da Costa Oliveira, Maria Tereza Oshitani, Histoshi Pandey, Nitin Paranhos-Baccala, Gláucia Phillips, Lia N. Scott, J. Anthony G. Sanchez Picot, Valentina Shen, Kunling Schweiger, Brunhilde Rahman, Mustafizur Rakoto-Andrianarivelo, Mala Rasmussen, Zeba A. Rath, Barbara A. Robinson, Annick Romero, Candice Russomando, Graciela Salimi, Vahid Sawatwong, Pongpun Seidenberg, Phil Sotomayor, Viviana Singleton, Rosalyn Scheltema, Nienke Strand, Tor A. Sutanto, Agustinos Sylla, Mariam Tapia, Milagritos D. Thamthitiwat, Somsak Ali, Asad Thomas, Elizabeth D. Nair, Harish RSV Global Epidemiology Network Tokarz, Rafal Turner, Claudia Venter, Marietjie Waicharoen, Sunthareeya Wang, Jianwei Watthanaworawit, Wanitda Yoshida, Lay-Myint Yu, Hongjie Zar, Heather J. Antonio, Martin Awori, Juliet O. Awasthi, Shally Campbell, Harry Azziz-Baumgartner, Eduardo Baggett, Henry C. Baillie, Vicky Balmaseda, Angel Barahona, Alfredo Basnet, Sudha Bassat Orellana, Quique Chipeta, James Chadha, Mandeep Basualdo, Wilma Bigogo, Godfrey Bont, Louis J. Breiman, Robert F. Brooks, Abdullah W. Broor, Shobha Bruce, Nigel Bruden, Dana Buchy, Philippe Campbell, Stuart Clara, Wilfrido Chou, Monidarin Carosone-Link, Phyllis Cohen, Cheryl Cuellar, Elizabeth de Dang, Duc-Anh Dash-Yandag, Budragchaagiin Deloria-Knoll, Maria Dherani, Mukesh Eap, Tekchheng Ebruke, Bernard E. Howie, Stephe R. C. Echavarria, Marcela de Freitas Lazaro Emediato, Carla Cecília Fasce, Rodrigo A. Feikin, Daniel R. Feng, Luzhao Gentile, Angela Gordon, Aubree Goswami, Doli Goyet, Sophie Homaira, Nusrat Jara, Jorge Groome, Michelle Halasa, Natasha Jroundi, Imane Kartasasmita, Cissy B. Khuri-Bulos, Najwa Kotloff, Karen L. Krishnan, Anand Libster, Romina Munywoki, Patrick Lopez, Olga Nicol, Mark P. Lucero, Marilla G. Lucion, Florencia Lupisan, Socorro P. Marcone, Debora N. McCracken, John P. Mejia, Mario Moisi, Jennifer C. Montgomery, Joel M. Moore, David P. Mutyara, Kuswandewi Nokes, D. James Moraleda Redecilla, Cinta |
Keywords: | Infeccions respiratòries Virologia mèdica Respiratory infections Medical virology |
Issue Date: | 6-Jul-2017 |
Publisher: | Elsevier |
Abstract: | BACKGROUND: We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration, we aimed to estimate the global incidence, hospital admission rate, and mortality from RSV-ALRI episodes in young children in 2015. METHODS: We estimated the incidence and hospital admission rate of RSV-associated ALRI (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions from a systematic review of studies published between Jan 1, 1995, and Dec 31, 2016, and unpublished data from 76 high quality population-based studies. We estimated the RSV-ALRI incidence for 132 developing countries using a risk factor-based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by combining in-hospital case fatality ratios with hospital admission estimates from hospital-based (published and unpublished) studies. We also estimated overall RSV-ALRI mortality by identifying studies reporting monthly data for ALRI mortality in the community and RSV activity. FINDINGS: We estimated that globally in 2015, 33.1 million (uncertainty range [UR] 21.6-50.3) episodes of RSV-ALRI, resulted in about 3.2 million (2.7-3.8) hospital admissions, and 59 600 (48 000-74 500) in-hospital deaths in children younger than 5 years. In children younger than 6 months, 1.4 million (UR 1.2-1.7) hospital admissions, and 27 300 (UR 20 700-36 200) in-hospital deaths were due to RSV-ALRI. We also estimated that the overall RSV-ALRI mortality could be as high as 118 200 (UR 94 600-149 400). Incidence and mortality varied substantially from year to year in any given population. INTERPRETATION: Globally, RSV is a common cause of childhood ALRI and a major cause of hospital admissions in young children, resulting in a substantial burden on health-care services. About 45% of hospital admissions and in-hospital deaths due to RSV-ALRI occur in children younger than 6 months. An effective maternal RSV vaccine or monoclonal antibody could have a substantial effect on disease burden in this age group. FUNDING: The Bill & Melinda Gates Foundation. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1016/S0140-6736(17)30938-8 |
It is part of: | Lancet, 2017, (17) 30938-8 |
URI: | http://hdl.handle.net/2445/114188 |
Related resource: | http://dx.doi.org/10.1016/S0140-6736(17)30938-8 |
ISSN: | 0140-6736 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Publicacions de projectes de recerca finançats per la UE |
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