Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/114188
Title: Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study
Author: Shi, Ting
McAllister, David A.
O'Brien, Katherine L.
Simoes, Eric A. F.
Madhi, Shabir A.
Gessner, Bradford D.
Polack, Fernando P.
Balsells, Evelyn
Acácio, Sozinho
Aguayo, Claudia
Alassani, Issifou
Nicol, Mark P.
Nokes, D. James
Nymadawa, Pagbajabyn
da Costa Oliveira, Maria Tereza
Oshitani, Histoshi
Pandey, Nitin
Paranhos-Baccala, Gláucia
Phillips, Lia N.
Scott, J. Anthony G.
Sanchez Picot, Valentina
Shen, Kunling
Rahman, Mustafizur
Rakoto-Andrianarivelo, Mala
Rasmussen, Zeba A.
Rath, Barbara A.
Robinson, Annick
Romero, Candice
Russomando, Graciela
Salimi, Vahid
Sawatwong, Pongpun
Seidenberg, Phil
Singleton, Rosalyn
Scheltema, Nienke
Schweiger, Brunhilde
Sotomayor, Viviana
Strand, Tor A.
Sutanto, Agustinos
Sylla, Mariam
Tapia, Milagritos D.
Thamthitiwat, Somsak
Ali, Asad
Thomas, Elizabeth D.
Nair, Harish
Tokarz, Rafal
Turner, Claudia
Venter, Marietjie
Waicharoen, Sunthareeya
Wang, Jianwei
Watthanaworawit, Wanitda
Yoshida, Lay-Myint
Yu, Hongjie
Zar, Heather J.
Antonio, Martin
Awasthi, Shally
Campbell, Harry
RSV Global Epidemiology Network
Awori, Juliet O.
Azziz-Baumgartner, Eduardo
Baggett, Henry C.
Baillie, Vicky L.
Balmaseda, Angel
Barahona, Alfredo
Basnet, Sudha
Bassat Orellana, Quique
Chipeta, James
Basualdo, Wilma
Bigogo, Godfrey
Bont, Louis
Breiman, Robert F.
Brooks, Abdullah W.
Broor, Shobha
Bruce, Nigel
Bruden, Dana
Buchy, Philippe
Campbell, Stuart
Chou, Monidarin
Carosone-Link, Phyllis
Chadha, Mandeep
Clara, Wilfrido
Cohen, Cheryl
de Cuellar, Elizabeth
Dang, Duc-Anh
Dash-Yandag, Budragchaagiin
Deloria-Knoll, Maria
Dherani, Mukesh
Eap, Tekchheng
Ebruke, Bernard E.
Echavarria, Marcela
de Freitas Lazaro Emediato, Carla Cecília
Fasce, Rodrigo A.
Feikin, Daniel R.
Feng, Luzhao
Gentile, Angela
Gordon, Aubree
Goswami, Doli
Goyet, Sophie
Homaira, Nusrat
Groome, Michelle
Halasa, Natasha
Howie, Stephe R. C.
Jara, Jorge
Jroundi, Imane
Kartasasmita, Cissy B.
Khuri-Bulos, Najwa
Kotloff, Karen L.
Krishnan, Anand
Libster, Romina
Munywoki, Patrick
Lopez, Olga
Lucero, Marilla G.
Lucion, Florencia
Lupisan, Socorro P.
Marcone, Debora N.
McCracken, John P.
Mejia, Mario
Moisi, Jennifer C.
Montgomery, Joel M.
Moore, David P.
Mutyara, Kuswandewi
Moraleda, Cinta
Moyes, Jocelyn
Keywords: Infeccions respiratòries
Virologia mèdica
Respiratory infections
Medical virology
Issue Date: 6-Jul-2017
Publisher: Elsevier
Abstract: BACKGROUND: We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration, we aimed to estimate the global incidence, hospital admission rate, and mortality from RSV-ALRI episodes in young children in 2015. METHODS: We estimated the incidence and hospital admission rate of RSV-associated ALRI (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions from a systematic review of studies published between Jan 1, 1995, and Dec 31, 2016, and unpublished data from 76 high quality population-based studies. We estimated the RSV-ALRI incidence for 132 developing countries using a risk factor-based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by combining in-hospital case fatality ratios with hospital admission estimates from hospital-based (published and unpublished) studies. We also estimated overall RSV-ALRI mortality by identifying studies reporting monthly data for ALRI mortality in the community and RSV activity. FINDINGS: We estimated that globally in 2015, 33.1 million (uncertainty range [UR] 21.6-50.3) episodes of RSV-ALRI, resulted in about 3.2 million (2.7-3.8) hospital admissions, and 59 600 (48 000-74 500) in-hospital deaths in children younger than 5 years. In children younger than 6 months, 1.4 million (UR 1.2-1.7) hospital admissions, and 27 300 (UR 20 700-36 200) in-hospital deaths were due to RSV-ALRI. We also estimated that the overall RSV-ALRI mortality could be as high as 118 200 (UR 94 600-149 400). Incidence and mortality varied substantially from year to year in any given population. INTERPRETATION: Globally, RSV is a common cause of childhood ALRI and a major cause of hospital admissions in young children, resulting in a substantial burden on health-care services. About 45% of hospital admissions and in-hospital deaths due to RSV-ALRI occur in children younger than 6 months. An effective maternal RSV vaccine or monoclonal antibody could have a substantial effect on disease burden in this age group. FUNDING: The Bill & Melinda Gates Foundation.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1016/S0140-6736(17)30938-8
It is part of: Lancet, 2017, (17) 30938-8
Related resource: http://dx.doi.org/10.1016/S0140-6736(17)30938-8
URI: http://hdl.handle.net/2445/114188
ISSN: 0140-6736
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