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Title: BDNF and NGF signalling in early phases of psychosis: relationship with inflammation and response to antipsychotics after a 1 year
Author: Martínez-Cengotitabengoa, Mónica
MacDowell, Karina S.
Alberich, Susana
Díaz, FJ.
García-Bueno, Borja
Rodriguez-Jimenez, R.
Bioque Alcázar, Miquel
Berrocoso, Esther
Parellada, Mara
Lobo, Antonio
Saiz, P.A.
Matute, Carlos
Bernardo Arroyo, Miquel
González-Pinto, Ana
Leza, Juan C.
Keywords: Psicosi
Trastorns afectius
Estudi de casos
Affective disorders
Antipsychotic drugs
Case studies
Issue Date: 30-Jun-2015
Publisher: Oxford University Press
Abstract: Previous studies have indicated systemic deregulation of the proinflammatory or anti-inflammatory balance in individuals with first-episode psychosis (FEP) that persists 12 months later. To identify potential risk/protective factors and associations with symptom severity, we assessed possible changes in plasma levels of neurotrophins (brain-derived neurotrophic factor [BDNF] and nerve growth factor [NGF]) and their receptors in peripheral blood mononuclear cells (PBMCs). Expression of the 2 forms of BDNF receptors (active TrkB-FL and inactiveTrkB-T1) in PBMCs of FEP patients changed over time, TrkB-FL expression increasing by 1 year after diagnosis, while TrkB-T1 expression decreased. The TrkB-FL/TrkB-T1 ratio (hereafter FL/T1 ratio) increased during follow-up in the nonaffective psychosis group only, suggesting different underlying pathophysiological mechanisms in subgroups of FEP patients. Further, the expression of the main NGF receptor, TrkA, generally increased in patients at follow-up. After adjusting for potential confounders, baseline levels of inducible isoforms of nitric oxide synthase, cyclooxygenase, and nuclear transcription factor were significantly associated with the FL/T1 ratio, suggesting that more inflammation is associated with higher values of this ratio. Interestingly, the FL/T1 ratio might have a role as a predictor of functioning, a regression model of functioning at 1 year suggesting that the effect of the FL/T1 ratio at baseline on functioning at 1 year depended on whether patients were treated with antipsychotics. These findings may have translational relevance; specifically, it might be useful to assess the expression of TrkB receptor isoforms before initiating antipsychotic treatment in FEPs
Note: Reproducció del document publicat a:
It is part of: Schizophrenia Bulletin, 2015, vol. 42, num. 1, p. 142-151
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ISSN: 0586-7614
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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