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Title: ApoA-I Mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer.
Author: Cedó Giné, Lídia
García León, Annabel
Baila Rueda, Lucía
Santos, David
Grijalva, Victor
Martínez Cignoni, Melanie Raquel
Carbo Marques, Jose Maria
Metso, Jari
López Vilaró, Laura
Zorzano Olarte, Antonio
Valledor Fernández, Annabel
Cenarro, Ana
Jauhiainen, Matti
Lerma, Enrique
Fogelman, Alan M.
Reddy, Srinivasa T.
Escolà i Gil, Joan Carles
Blanco-Vaca, Francisco
Keywords: Càncer de mama
Ratolins transgènics
Breast cancer
High density lipoproteins
Transgenic mice
Issue Date: 3-Nov-2016
Publisher: Nature Publishing Group
Abstract: Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification
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It is part of: Scientific Reports, 2016, vol. 6, p. 36387
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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