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Title: Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice
Author: Alcalá, Martín
Calderón Domínguez, María
Bustos, Eduviges
Ramos, Pilar
Casals i Farré, Núria
Serra i Cucurull, Dolors
Viana Arribas, Marta
Herrero Rodríguez, Laura
Keywords: Obesitat
Teixit adipós
Estrès oxidatiu
Adipose tissues
Oxidative stress
Issue Date: 22-Nov-2017
Publisher: Nature Publishing Group
Abstract: Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases has been strongly related to white adipose tissue (WAT) dysfunction through several mechanisms such as fibrosis, apoptosis, inflammation, ER and oxidative stress. However, little is known of whether these processes are also present in brown adipose tissue (BAT) during obesity, and the potential consequences on mitochondrial activity. Here we characterized the BAT of obese and hyperglycemic mice treated with a high-fat diet (HFD) for 20 weeks. The hypertrophic BAT from obese mice showed no signs of fibrosis nor apoptosis, but higher levels of inflammation, ER stress, ROS generation and antioxidant enzyme activity than the lean counterparts. The response was attenuated compared with obesity-induced WAT derangements, which suggests that BAT is more resistant to the obesity-induced insult. In fact, mitochondrial respiration in BAT from obese mice was enhanced, with a 2-fold increase in basal oxygen consumption, through the upregulation of complex III of the electron transport chain and UCP1. Altogether, our results show that obesity is accompanied by an increase in BAT mitochondrial activity, inflammation and oxidative damage.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2017, vol. 7, num. 1, p. 16082
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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