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Title: Solvent-controlled diastereoselectivity in tryptophan-catalyzed Mannich reactions
Author: Valero González, Guillem
León, Carlos M.
Moyano i Baldoire, Albert
Keywords: Aminoàcids
Catàlisi asimètrica
Amino acids
Enantioselective catalysis
Issue Date: 12-Jun-2015
Publisher: De Gruyter Open
Abstract: Solvent effects in the L-tryptophan-catalyzed Mannich reaction between hydroxyacetone and glyoxylate imines have been examined. The use of a DMSO/1-butanol (4:1 v/v) mixture as solvent at rt provided the expected Mannich adducts in good yields, high anti-diastereoselectivity (up to 10.3:1 anti/syn ratio) and excellent enantioselectivities (up to >99.9% ee for the anti isomer)
It is part of: Asymmetric Catalysis, 2015, vol. 2, num. 1, p. 7-16
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ISSN: 2300-4630
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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