Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/119967| Title: | Solvent-controlled diastereoselectivity in tryptophan-catalyzed Mannich reactions |
| Author: | Valero González, Guillem León, Carlos M. Moyano i Baldoire, Albert |
| Keywords: | Aminoàcids Catàlisi asimètrica Amino acids Enantioselective catalysis |
| Issue Date: | 12-Jun-2015 |
| Publisher: | De Gruyter Open |
| Abstract: | Solvent effects in the L-tryptophan-catalyzed Mannich reaction between hydroxyacetone and glyoxylate imines have been examined. The use of a DMSO/1-butanol (4:1 v/v) mixture as solvent at rt provided the expected Mannich adducts in good yields, high anti-diastereoselectivity (up to 10.3:1 anti/syn ratio) and excellent enantioselectivities (up to >99.9% ee for the anti isomer) |
| Note: | https://doi.org/10.1515/asorg-2015-0001 |
| It is part of: | Asymmetric Catalysis, 2015, vol. 2, num. 1, p. 7-16 |
| URI: | http://hdl.handle.net/2445/119967 |
| Related resource: | https://doi.org/10.1515/asorg-2015-0001 |
| ISSN: | 2300-4630 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 668850.pdf | 525.43 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License
