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Title: A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression
Author: Navarro Brugal, Gemma
Martínez-Pinilla, Eva
Sánchez Melgar, Alejandro
Ortiz, Raquel
Noé Mata, Verónica
Martín, Mairena
Ciudad i Gómez, Carlos Julián
Franco Fernández, Rafael
Keywords: Expressió gènica
Sistema nerviós central
Gene expression
Central nervous system
Issue Date: 25-Apr-2017
Publisher: Public Library of Science (PLoS)
Abstract: The mode of action of trans-resveratrol, a promising lead compound for the development of neuroprotective drugs, is unknown. Data from a functional genomics study were retrieved with the aim to find differentially expressed genes that may be involved in the benefits provided by trans-resveratrol. Genes that showed a significantly different expression (p<0.05, cut-off of a two-fold change) in mice fed with a control diet or a control diet containing trans-resveratrol were different in cortex, heart and skeletal muscle. In neocortex, we identified 4 up-regulated (Strap, Pkp4, Rab2a, Cpne3) and 22 down-regulated (Actn1, Arf3, Atp6v01, Atp1a3, Atp1b2, Cacng7, Crtc1, Dbn1, Dnm1, Epn1, Gfap, Hap, Mark41, Rab5b, Nrxn2, Ogt, Palm, Ptprn2, Ptprs, Syn2, Timp2, Vamp2) genes upon trans-resveratrol consumption. Network analysis of gene products provided evidence of plakophilin 4 up-regulation as a triggering factor for down-regulation of events related to synaptic vesicle transport and neurotransmitter release via underexpression of dynamin1 and Vamp2 (synaptobrevin 2) as node-gene drivers. Analysis by RT-qPCR of some of the selected genes in a glioma cell line showed that dynamin 1 mRNA was down-regulated even in acute trans-resveratrol treatments. Taken all together, these results give insight on the glial-neuronal networks involved in the neuroprotective role of trans-resveratrol.
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It is part of: PLoS One, 2017, vol. 12, num. 4, p. e0176067
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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