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http://hdl.handle.net/2445/121044
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DC Field | Value | Language |
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dc.contributor.author | Vilà-Balló, Adrià | - |
dc.contributor.author | François, Clément | - |
dc.contributor.author | Cucurell, David | - |
dc.contributor.author | Miró, Júlia | - |
dc.contributor.author | Falip, Mercè | - |
dc.contributor.author | Juncadella i Puig, Montserrat | - |
dc.contributor.author | Rodríguez Fornells, Antoni | - |
dc.date.accessioned | 2018-03-23T07:40:45Z | - |
dc.date.available | 2018-03-23T07:40:45Z | - |
dc.date.issued | 2017-05-09 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/121044 | - |
dc.description.abstract | The capacity to respond to novel events is crucial for adapting to the constantly changing environment. Here, we recorded 29-channel Event Related Brain Potentials (ERPs) during an active auditory novelty oddball paradigm and used for the first time Current Source Density-transformed Event Related Brain Potentials and associated time-frequency spectra to study target and novelty processing in a group of epileptic patients with unilateral damage of the hippocampus (N = 18) and in healthy matched control participants (N = 18). Importantly, we used Voxel-Based Morphometry to ensure that our group of patients had a focal unilateral damage restricted to the hippocampus and especially its medial part. We found a clear deficit for target processing at the behavioral level. In addition, compared to controls, our group of patients presented (i) a reduction of theta event-related synchronization (ERS) for targets and (ii) a reduction and delayed P3a source accompanied by reduced theta and low-beta ERS and alpha event-related synchronization (ERD) for novel stimuli. These results suggest that the integrity of the hippocampus might be crucial for the functioning of the complex cortico-subcortical network involved in the detection of novel and target stimuli. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-01531-8 | - |
dc.relation.ispartof | Scientific Reports, 2017, num. 7, p. 1612 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-017-01531-8 | - |
dc.rights | cc-by (c) Vilà-Balló, Adrià et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) | - |
dc.subject.classification | Hipocamp (Cervell) | - |
dc.subject.classification | Percepció auditiva | - |
dc.subject.classification | Cognició | - |
dc.subject.classification | Atenció | - |
dc.subject.other | Hippocampus (Brain) | - |
dc.subject.other | Auditory perception | - |
dc.subject.other | Cognition | - |
dc.subject.other | Attention | - |
dc.title | Auditory target and novelty processing in patients with unilateral hippocampal sclerosis: A current-source density study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 671431 | - |
dc.date.updated | 2018-03-23T07:40:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28487515 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) |
Files in This Item:
File | Description | Size | Format | |
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671431.pdf | 2.08 MB | Adobe PDF | View/Open |
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