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Title: Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
Author: Lagunas, Anna
Martínez, Elena
Samitier i Martí, Josep
Keywords: Diferenciació cel·lular
Morfologia (Biologia)
Cell diferentiation
Morphology (Biology)
Issue Date: 31-Aug-2015
Publisher: Frontiers Media
Abstract: Chemical gradient surfaces are described as surfaces with a gradually varying composition along their length. Continuous chemical gradients have recently been proposed as an alternative to discrete microarrays for the high-throughput screening of the effects of ligand concentration in cells. Here, we review some of the most recent examples in which gradients have been used to evaluate the effect of a varying ligand concentration in cell adhesion, morphology, growth, and differentiation of cells, including some of our recent findings. They show the importance of the organization of ligands at the nanoscale, which is highlighted by abrupt changes in cell behavior at critical concentration thresholds.
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It is part of: Frontiers in Bioengineering and Biotechnology, 2015, vol. 3, num. 132
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ISSN: 2296-4185
Appears in Collections:Articles publicats en revistes (Electrònica)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Publicacions de projectes de recerca finançats per la UE

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