Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/122132
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Castro Catala, Marta de | - |
dc.contributor.author | Mora Solano, Aurea | - |
dc.contributor.author | Kwapil, Thomas R. | - |
dc.contributor.author | Cristóbal Narváez, Paula | - |
dc.contributor.author | Sheinbaum, Tamara | - |
dc.contributor.author | Racioppi, Anna | - |
dc.contributor.author | Barrantes Vidal, Neus | - |
dc.contributor.author | Rosa de la Cruz, Araceli | - |
dc.date.accessioned | 2018-05-07T11:41:48Z | - |
dc.date.available | 2018-05-07T11:41:48Z | - |
dc.date.issued | 2017-09-20 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/122132 | - |
dc.description.abstract | Background: The Zinc finger protein 804A (ZNF804A) is a promising candidate gene for schizophrenia and the broader psychosis phenotype that emerged from genome-wide association studies. It is related to neurodevelopment and associated to severe symptoms of schizophrenia and alterations in brain structure, as well as positive schizotypal personality traits in non-clinical samples. Moreover, a female-specific association has been observed between ZNF804A and schizophrenia. Aim: The present study examined the association of two ZNF804A polymorphisms (rs1344706 and rs7597593) with the positive dimension of schizotypy and psychotic-like experiences in a sample of 808 non-clinical subjects. Additionally, we wanted to explore whether the sexual differences reported in schizophrenia are also present in psychosis-proneness. Results: Our results showed an association between rs7597593 and both schizotypy and psychotic-like experiences. These associations were driven by females, such those carrying the C allele had higher scores in the positive dimension of both variables compared to TT allele homozygotes. Conclusion: The findings of the present study support the inclusion of ZNF804 variability in studies of the vulnerability for the development of psychopathology in non-clinical samples and consideration of sex as a moderator of this association. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0185072 | - |
dc.relation.ispartof | PLoS One, 2017, vol. 12, num. 9, p. e0185072 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0185072 | - |
dc.rights | cc-by (c) Castro Catala, Marta de et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) | - |
dc.subject.classification | Esquizofrènia | - |
dc.subject.classification | Psicosi | - |
dc.subject.classification | Genòmica | - |
dc.subject.other | Schizophrenia | - |
dc.subject.other | Psychoses | - |
dc.subject.other | Genomics | - |
dc.title | The genome-wide associated candidate gene ZNF804A and psychosis-proneness: Evidence of sex-modulated association | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 673616 | - |
dc.date.updated | 2018-05-07T11:41:48Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28931092 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
673616.pdf | 955.3 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License