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Title: | Effect of oral anticoagulants on the outcome of faecal immunochemical test |
Author: | Bujanda, Luis Sarasqueta, Cristina Lanas, Angel Quintero, Enrique Cubiella, Joaquín Hernández, Vicent Morillas, Juan D. Perez-Fernández, T. Salas, D. Andreu, Montserrat Carballo, F. Bessa i Caserras, Xavier Portillo, I. Jover, Rodrigo Balaguer Prunés, Francesc Cosme, Ángel Castells Garangou, Antoni |
Keywords: | Càncer colorectal Anticoagulants (Medicina) Immunoquímica Colonoscòpia Estudi de casos Colorectal cancer Anticoagulants (Medicine) Immunochemistry Colonoscopy Case studies |
Issue Date: | 4-Feb-2014 |
Publisher: | Cancer Research UK |
Abstract: | Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml-1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend ¼ 0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P ¼ 0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P ¼ 0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/bjc.2014.38 |
It is part of: | British Journal of Cancer, 2014, vol. 110, num. 5, p. 1334-1337 |
URI: | http://hdl.handle.net/2445/122159 |
Related resource: | https://doi.org/10.1038/bjc.2014.38 |
ISSN: | 0007-0920 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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