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Title: Effect of oral anticoagulants on the outcome of faecal immunochemical test
Author: Bujanda, Luis
Sarasqueta, Cristina
Lanas, Angel
Quintero, Enrique
Cubiella, Joaquín
Hernández, Vicent
Morillas, Juan D.
Perez-Fernández, T.
Salas, D.
Andreu, Montserrat
Carballo, F.
Bessa i Caserras, Xavier
Portillo, I.
Jover, Rodrigo
Balaguer Prunés, Francesc
Cosme, Ángel
Castells Garangou, Antoni
Keywords: Càncer colorectal
Anticoagulants (Medicina)
Estudi de casos
Colorectal cancer
Anticoagulants (Medicine)
Case studies
Issue Date: 4-Feb-2014
Publisher: Cancer Research UK
Abstract: Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening. Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml-1) between November 2008 and June 2011. Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend ¼ 0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P ¼ 0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P ¼ 0.4). Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.
Note: Reproducció del document publicat a:
It is part of: British Journal of Cancer, 2014, vol. 110, num. 5, p. 1334-1337
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ISSN: 0007-0920
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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