Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/122332
Title: Cytotoxic evaluation of (2S)-5,7-dihydroxy-6-prenylflavanone derivatives loaded PLGA nanoparticles against MiaPaCa-2 cells
Author: Andrade Carrera, Berenice
Clares Naveros, Beatriz
Noé Mata, Verónica
Mallandrich Miret, Mireia
Calpena Campmany, Ana Cristina
García López, María Luisa
Garduño Ramírez, María Luisa
Keywords: Mort cel·lular
Càncer
Cell death
Cancer
Issue Date: 15-Sep-2017
Publisher: MDPI
Abstract: The search for new alternatives for the prevention and treatment of cancer is extremely important to minimize human mortality. Natural products are an alternative to chemical drugs, since they are a source of many potential compounds with anticancer properties. In the present study, the (2S)-5,7-dihydroxy-6-prenylflavanone (semi-systematic name), also called (2S)-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-2-phenyl-2,3-dihydro-4H-1-Benzopyran-4-one (CAS Name registered) (1) was isolated from Eysenhardtia platycarpa leaves. This flavanone 1 was considered as the lead compound to generate new cytotoxic derivatives 1a, 1b, 1c and 1d. These compounds 1, 1a, 1b, 1c, and 1d were then loaded in nanosized drug delivery systems such as polymeric nanoparticles (NPs). Small homogeneous spherical shaped NPs were obtained. Cytotoxic activity of free compounds 1, 1a, 1b, 1c, and 1d and encapsulated in polymeric NPs (NPs1, NPs1a, NPs1b, NPs1c and NPs1d) were evaluated against the pancreatic cancer cell line MiaPaCa-2. The obtained results demonstrated that NPs1a and NPs1b exhibited optimal cytotoxicity, and an even higher improvement of the cytotoxic efficacy was exhibited with the encapsulation of 1a. Based on these results, NPs1a were proposed as promising anticancer agent candidates.
Note: Reproducció del document publicat a: https://doi.org/10.3390/molecules22091553
It is part of: Molecules, 2017, vol. 22(9), num. 1553
URI: http://hdl.handle.net/2445/122332
Related resource: https://doi.org/10.3390/molecules22091553
ISSN: 1420-3049
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Files in This Item:
File Description SizeFormat 
673741.pdf4.87 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons