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Title: Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer
Author: Navarro Brugal, Gemma
Carriba, Paulina
Gandía, Jorge
Ciruela Alférez, Francisco
Casadó, Vicent
Cortés Tejedor, Antonio
Mallol Montero, Josefa
Canela Campos, Enric I.
Lluís i Biset, Carme
Franco Fernández, Rafael
Keywords: Adenosina
Receptors cel·lulars
Cell receptors
Issue Date: 11-Oct-2008
Publisher: Hindawi
Abstract: Functional interactions in signaling occur between dopamine D2 (D2R) and cannabinoid CB1 (CB1R) receptors, between CB1R and adenosine A2A (A2AR) receptors, and between D2R and A2AR. Furthermore, direct molecular interactions have been reported for the pairs CB1R-D2R, A2AR-D2R, and CB1R-A2AR. Here a combination of bimolecular fluorescence complementation and bioluminescence energy transfer techniques was used to identify the occurrence of D2R-CB1R-A2AR hetero-oligomers in living cells.
Note: Reproducció del document publicat a:
It is part of: Scientific World Journal, 2008, vol. 8, p. 1088-1097
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ISSN: 1537-744X
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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