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dc.contributor.authorNavarro Brugal, Gemma-
dc.contributor.authorQuiroz, César-
dc.contributor.authorMoreno-Delgado, David-
dc.contributor.authorSierakowiak, Adam-
dc.contributor.authorMcDowell, Kimberly-
dc.contributor.authorMoreno Guillén, Estefanía-
dc.contributor.authorRea, William-
dc.contributor.authorCai, Ning-Sheng-
dc.contributor.authorAguinaga Andrés, David-
dc.contributor.authorHowell, Lesley A.-
dc.contributor.authorHausch, Felix-
dc.contributor.authorCortés Tejedor, Antonio-
dc.contributor.authorMallol Montero, Josefa-
dc.contributor.authorCasadó, Vicent-
dc.contributor.authorLluís i Biset, Carme-
dc.contributor.authorCanela Campos, Enric I.-
dc.contributor.authorFerré, Sergi-
dc.contributor.authorMcCormick, Peter J.-
dc.description.abstractRelease of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior. We provide evidence for pharmacologically significant interactions between CRF and orexin-A that depend on oligomerization of CRF1 receptor (CRF1R) and orexin OX1 receptors (OX1R). CRF1R-OX1R heteromers are the conduits of a negative crosstalk between orexin-A and CRF as demonstrated in transfected cells and rat VTA, in which they significantly modulate dendritic dopamine release. The cocaine target sigma1 receptor (sigma1R) also associates with the CRF1R-OX1R heteromer. Cocaine binding to the sigma1R-CRF1R-OX1R complex promotes a long-term disruption of the orexin-A-CRF negative crosstalk. Through this mechanism, cocaine sensitizes VTA cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces cocaine seeking.-
dc.format.extent15 p.-
dc.publisherThe Society for Neuroscience-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofJournal of Neuroscience, 2015, vol. 35, num. 17, p. 6639-6653-
dc.rightscc-by-nc-sa (c) Navarro Brugal, Gemma et al., 2015-
dc.subject.classificationReceptors cel·lulars-
dc.subject.otherCell receptors-
dc.titleOrexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine-
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Bioquímica i Fisiologia)

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