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http://hdl.handle.net/2445/122911
Title: | Hippeastrum reticulatum (Amaryllidaceae): Alkaloid profiling, biological activities and molecular docking |
Author: | Tallini, Luciana R. Osorio, Edison H. Dias dos Santos, Vanessa Souza Borges, Warley de Kaiser, Marcel Viladomat Meya, Francesc Zuanazzi, José Ângelo Silveira Bastida Armengol, Jaume |
Keywords: | Plantes bulboses Alcaloides Bulb plants Alkaloids |
Issue Date: | 9-Dec-2017 |
Publisher: | MDPI |
Abstract: | The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6α-hydroxymaritidine and 6β-hydroxymaritidine). Twelve alkaloids were identified in H. reticulatum: eight known alkaloids by GC-MS and four unknown (6α-hydroxymaritidine, 6β-hydroxymaritidine, reticulinine and isoreticulinine) by NMR. The epimer mixture (6α-hydroxymaritidine and 6β-hydroxymaritidine) showed low activity against all protozoan parasites tested and weak AChE-inhibitory activity. Finally, a molecular docking analysis of AChE and BuChE proteins showed that isoreticulinine may be classified as a potential inhibitory molecule since it can be stabilized in the active site through hydrogen bonds, π-π stacking and hydrophobic interactions. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/molecules22122191 |
It is part of: | Molecules, 2017, vol. 22, num. 12, p. 2191 |
URI: | http://hdl.handle.net/2445/122911 |
Related resource: | https://doi.org/10.3390/molecules22122191 |
ISSN: | 1420-3049 |
Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) |
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