Please use this identifier to cite or link to this item:
Title: Magnetotactic bacteria powered biohybrids target E. coli biofilms
Author: Stanton, Morgan M.
Park, Byung-Wook
Vilela, Diana
Bente, Klaas
Faivre, Damien
Sitti, Metin
Sánchez Ordóñez, Samuel
Keywords: Bacteris
Escheríchia coli
Escherichia coli
Issue Date: 1-Sep-2017
Publisher: American Chemical Society
Abstract: Biofilm colonies are typically resistant to general antibiotic treatment and require targeted methods for their removal. One of these methods include the use of nanoparticles as carriers for antibiotic delivery, where they randomly circulate in fluid until they make contact with the infected areas. However, the required proximity of the particles to the biofilm results in only moderate efficacy. We demonstrate here that the non-pathogenic magnetotactic bacteria, Magnetosopirrillum gryphiswalense (MSR-1), can be integrated with drug-loaded mesoporous silica microtubes (MSMs) to build controllable microswimmers (biohybrids) capable of antibiotic delivery to target an infectious biofilm. Applying external magnetic guidance capability and swimming power of the MSR-1 cells, the biohybrids are directed to and forcefully pushed into matured Escherichia coli (E. coli) biofilms. Release of the antibiotic, ciprofloxacin (CFX), is triggered by the acidic microenvironment of the biofilm ensuring an efficient drug delivery system. The results reveal the capabilities of a non-pathogenic bacteria species to target and dismantle harmful biofilms, indicating biohybrid systems have great potential for anti-biofilm applications.
Note: Reproducció del document publicat a:
It is part of: ACS Nano, 2017, vol. 11, num. 10, p. 9968-9978
Related resource:
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Files in This Item:
File Description SizeFormat 
L21_2017_ACS Nano_11_9968.pdf9.29 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.