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Title: Comparative study of ex vivo transmucosal permeation of Pioglitazone nanoparticles for the treatment of Alzheimer's disease
Author: Silva Abreu, Marcelle
Espinoza, Lupe Carolina
Halbaut, Lyda
Espina García, Marta
García López, María Luisa
Calpena Campmany, Ana Cristina
Keywords: Sistemes d'alliberament de medicaments
Membrana mucosa
Malaltia d'Alzheimer
Drug delivery systems
Mucous membrane
Alzheimer's disease
Issue Date: 2018
Publisher: MDPI
Abstract: Pioglitazone has been reported in the literature to have a substantial role in the improvement of overall cognition in a mouse model. With this in mind, the aim of this study was to determine the most efficacious route for the administration of Pioglitazone nanoparticles (PGZ-NPs) in order to promote drug delivery to the brain for the treatment of Alzheimer's disease. PGZ-loaded NPs were developed by the solvent displacement method. Parameters such as mean size, polydispersity index, zeta potential, encapsulation efficacy, rheological behavior, and short-term stability were evaluated. Ex vivo permeation studies were then carried out using buccal, sublingual, nasal, and intestinal mucosa. PGZ-NPs with a size around of 160 nm showed high permeability in all mucosae. However, the permeation and prediction parameters revealed that lag-time and vehicle/tissue partition coefficient of nasal mucosa were significantly lower than other studied mucosae, while the diffusion coefficient and theoretical steady-state plasma concentration of the drug were higher, providing biopharmaceutical results that reveal more favorable PGZ permeation through the nasal mucosa. The results suggest that nasal mucosa represents an attractive and non-invasive pathway for PGZ-NPs administration to the brain since the drug permeation was demonstrated to be more favorable in this tissue. View Full-Text Keywords: nanoparticles; pioglitazone; PLGA-PEG; transmucosal permeations; Alzheimer's disease
Note: Reproducció del document publicat a:
It is part of: Polymers, 2018, vol. 10, num. 3, p. 316
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ISSN: 2073-4360
Appears in Collections:Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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