Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/124884
Title: | The role of genetic variability in the SLC6A4, BDNF and GABRA6 genes in anxiety related traits |
Author: | Arias Sampériz, Bárbara Aguilera, María del Carmen Moya Higueras, Jorge Sáiz Martínez, Pilar Alejandra Villa, H. Ibáñez Ribes, Manuel Ignacio García-Portillo, M.A. Ruipérez Rodríguez, María Ángeles Bobes García, Julio Ortet i Fabregat, Generós Fañanás Saura, Lourdes |
Keywords: | Gens Ansietat Genes Anxiety |
Issue Date: | 27-Feb-2012 |
Publisher: | John Wiley & Sons |
Abstract: | The aims of this study were to test the individual association of the 5-HTT, BDNF, and GABRA6 genes with anxiety-related traits and to explore putative GxG interactions in a healthy sample. Method: A sample of 937 individuals from the general population completed the TCI questionnaire; a subsample of 553 individuals also filled in a brief version of the NEO inventory. The whole sample was genotyped for the 5-HTTLPR polymorphism (5- HTT gene), the Val66Met polymorphism (BDNF gene) and the T1521C polymorphism (GABRA6 gene). Results: Individuals carrying the TTgenotype of the T1512C polymorphism presented slightly higher scores for Harm Avoidance ( HA ) than C allele carriers (F=2.96, p=0.051). In addition, there was a significant GxG interaction on HA between the 5-HTTLPR and Val66Met polymorphisms (F=3.4, p=0.009). Conclusion: GABRA6 emerges as a putative gene may be involved in the variability of HA. The effect of a significant GxG interaction between the 5-HTT and BDNF genes on HA could explain part of the genetic basis underlying anxiety-related traits. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1111/j.1600-0447.2011.01764.x |
It is part of: | Acta Psychiatrica Scandinavica, 2012, vol. 125, p. 194-202 |
URI: | http://hdl.handle.net/2445/124884 |
Related resource: | https://doi.org/10.1111/j.1600-0447.2011.01764.x |
ISSN: | 0001-690X |
Appears in Collections: | Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) |
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