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Title: Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium
Author: Huang, Ruyi
Wei, Yongyue
Hung, Rayjean J.
Liu, Geoffrey
Su, Li
Zhang, Ruyang
Zong, Xuchen
Zhang, Zuo-Feng
Morgenstern, Hal
Brüske, Irene
Heinrich, Joachim
Hong, Yun-Chul
Kim, Jin Hee
Cote, Michele
Wenzlaff, Angela
Schwartz, Ann G.
Stucker, Isabelle
McLaughlin, John R.
Marcus, Michael W.
Davies, Michael P. A.
Liloglou, Triantafillos
Field, John K.
Matsuo, Keitaro
Barnett, Matt
Thornquist, Mark D.
Goodman, Gary E.
Wang, Yi
Chen, Size
Yang, Ping
Duell, Eric J.
Andrew, Angeline S.
Lazarus, Philip
Muscat, Joshua E.
Woll, Penella
Horsman, Janet
Teare, M. Dawn
Flugelman, Anath
Rennert, Gad
Zhang, Yan
Brenner, Hermann
Stegmaier, Christa
van der Heijden, Erik H. F. M.
Aben, Katja K.
Kiemeney, Lambertus A. L. M.
Barros Dios, Juan
Pérez Rios, Mónica
Ruano Ravina, Alberto
Caporaso, Neil E.
Bertazzi, Pier Alberto
Landi, Maria Teresa
Dai, Juncheng
Shen, Hongbing
Fernandez Tardon, Guillermo
Rodriguez Suarez, Marta
Tardón, Adonina
Christiani, David C.
Keywords: Malalties pulmonars obstructives cròniques
Càncer de pulmó
Chronic obstructive pulmonary diseases
Lung cancer
Issue Date: Nov-2015
Publisher: Elsevier
Abstract: Background: The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention. Methods: We included 24 studies from the ILCCO collaboration. Random-effects panel logistic regression and cubic spline regression were used to estimate the effects of smoking behaviors on SCLC risk and explore their non-linearity. Further, we explored whether the risk of smoking on SCLC was mediated through COPD. Findings: Significant dose-response relationships of SCLC risk were observed for all quantitative smoking variables. Smoking pack-years were associated with a sharper increase of SCLC risk for pack-years ranged 0 to approximately 50. The former smokers with longer cessation showed a 43%(quit_for_5-9 years) to 89%(quit_for_>= 20 years) declined SCLC risk vs. subjects who had quit smoking <5 years. Compared with non-COPD subjects, smoking behaviors showed a significantly higher effect on SCLC risk among COPD subjects, and further, COPD patients showed a 1.86-fold higher risk of SCLC. Furthermore, smoking behaviors on SCLC risk were significantly mediated through COPD which accounted for 0.70% to 7.55% of total effects. Interpretation: This is the largest pooling study that provides improved understanding of smoking on SCLC, and further demonstrates a causal pathway through COPD that warrants further experimental study.
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It is part of: Ebiomedicine, 2015, vol. 2, num. 11, p. 1677-1685
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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