Title: | Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
Author: | Berndt, Sonja I. Camp, Nicola J. Skibola, Christine F. Vijai, Joseph Wang, Zhaoming Gu, Jian Nieters, Alexandra Kelly, Rachel S. Smedby, Karin E. Monnereau, Alain Cozen, Wendy North, Kari E. Liang, Liming Cox, Angela Crouch, Simon Park, Ju-Hyun Chatterjee, Nilanjan Zhang, Yawei Snowden, John A. Wright, Josh Fraumeni, Joseph F. Montalvan, Rebecca Rothman, Nathaniel Offit, Kenneth Cocco, Pierluigi Sanjosé Llongueras, Silvia de Cerhan, James R. Chanock, Stephen J. Novak, Anne J. Slager, Susan L. Lan, Qing Teras, Lauren R. Birmann, Brenda M. Machado, Moara Shanafelt, Tait D. Brooks-Wilson, Angela R. Hartge, Patricia Purdue, Mark P. Chang, Ellen T. Vajdic, Claire M. Giles, Graham G. Zeleniuch-Jacquotte, Anne Lawrence, Charles Conde, Lucía Burdett, Laurie Hutchinson, Amy Ye, Yuanqing Zhi, Degui Allmer, Cristine Call, Timothy G. Weiner, George J. Kay, Neil E. Liebow, Mark Cunningham, Julie M. Sala Serra, Núria Hjalgrim, Henrik Adami, Hans-Olov Melbye, Mads Diver, W. Ryan Glimelius, Bengt Benavente, Yolanda Glenn, Martha Curtin, Karen Cannon-Albright, Lisa A. Chaffee, Kari G. Link, Brian K. Bracci, Paige M. Riby, Jacques Arnett, Donna K. Caporaso, Neil E. Leach, Justin M. Holly, Elizabeth A. Jackson, Rebecca D. J. Severson, Richard K. Brennan, Paul Tinker, Lesley F. Weinberg, J. Brice Casabonne, Delphine Becker, Nikolaus Boffetta, Paolo Chirlaque, María Dolores Foretova, Lenka Maynadié, Marc McKay, James D. Strom, Sara S. Staines, Anthony Weiderpass, Elisabete Achenbach, Sara J. Vachon, Celine M. Goldin, Lynn R. Zheng, Tongzhang Leis, Jose F. Norman, Aaron D. Roos, Anneclaire J. De Morton, Lindsay M. Bertrand, Kimberly A. Riboli, Elio Vineis, Paolo Kaaks, Rudolf Turner, Jenny Milne, Roger L. Masala, Giovanna Connors, Joseph M. Vermeulen, Roel C. H. Travis, Ruth C. Southey, Melissa C. Huang, Jinyan Albanes, Demetrius Virtamo, Jarmo Weinstein, Stephanie J. Spinelli, John J. Clavel, Jacqueline Ma, Baoshan Holford, Theodore R. Villano, Danylo J. Maria, Ann Wu, Xifeng Gascoyne, Randy D. Giovannucci, Edward L. Kraft, Peter Kricker, Anne Wang, Sophia S. Ennas, Maria Grazia Ferri, Giovanni M. Miligi, Lucia Yeager, Meredith |
Keywords: | Leucèmia limfocítica crònica Malalties hereditàries Chronic lymphocytic leukemia Genetic disorders |
Issue Date: | 9-Mar-2016 |
Publisher: | Nature Publishing |
Abstract: | Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/ncomms10933 |
It is part of: | Nature Communications, 2016, vol. 7 |
URI: | http://hdl.handle.net/2445/126875 |
Related resource: | https://doi.org/10.1038/ncomms10933 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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