Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/127968
Title: Risk model for colorectal cancer in spanish population using environmental and genetic factors: results from the MCC-Spain study
Author: Ibáñez Sanz, Gemma
Díez Villanueva, Anna
Alonso Aguado, Maria Henar
Rodríguez Moranta, Francisco
Pérez Gómez, Beatriz
Bustamante Pineda, Mariona
Martín Sánchez, Vicente
Llorca Díaz, Javier
Amiano, Pilar
Ardanaz, Eva
Tardón, Adonina
Jiménez Moleón, José Juan
Peiró Pérez, Rosana
Alguacil, Juan
Navarro Sánchez, Carmen
Guinó, Elisabet
Binefa i Rodríguez, Gemma
Fernández Navarro, Pablo
Espinosa Cardiel, Ana
Dávila Batista, Verónica
Molina de la Torre, Antonio José
Palazuelos-Calderón, Camilo
Aragonès Sanz, Núria
Kogevinas, Manolis
Pollán, Marina
Moreno Aguado, Víctor
Keywords: Càncer colorectal
Espanya
Genètica
Epidemiologia
Influència del medi ambient en l'home
Factors de risc en les malalties
Colorectal cancer
Spain
Genetics
Epidemiology
Environmental effects on human beings
Risk factors in diseases
Issue Date: 24-Feb-2017
Publisher: Nature Publishing Group
Abstract: Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.
Note: Aquest article conté una errata annexada
Note: Reproducció del document publicat a: https://doi.org/10.1038/srep43263
It is part of: Scientific Reports, 2017, vol. 7, p. 43263
URI: http://hdl.handle.net/2445/127968
Related resource: https://doi.org/10.1038/srep43263
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Ciències Clíniques)

Files in This Item:
File Description SizeFormat 
671476.pdf967.03 kBAdobe PDFView/Open
671476_errata.pdf110.83 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons