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http://hdl.handle.net/2445/128081
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DC Field | Value | Language |
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dc.contributor.author | Wang, Ninghai | - |
dc.contributor.author | Keszei, Marton | - |
dc.contributor.author | Halibozek, Peter J. | - |
dc.contributor.author | Yigit, Burcu | - |
dc.contributor.author | Engel Rocamora, Pablo | - |
dc.contributor.author | Terhorst, Cox | - |
dc.date.accessioned | 2019-02-08T15:30:18Z | - |
dc.date.available | 2019-02-08T15:30:18Z | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1521-6616 | - |
dc.identifier.uri | http://hdl.handle.net/2445/128081 | - |
dc.description.abstract | The nine SLAM family (Slamf) receptors are positive or negative regulators of adaptive and innate immune responses, and of several autoimmune diseases. Here we report that the transfer of Slamf6-/- B6 CD4+ T cells into co-isogenic bm12 mice causes SLE-like autoimmunity with elevated levels of autoantibodies. In addition, significantly higher percentages of Tfh cells and IFN-γ-producing CD4+ cells, as well as GC B cells were observed. Interestingly, the expression of the Slamf6-H1 isoform in Slamf6-/- CD4+ T cells did not induce this lupus-like phenotype. By contrast, Slamf1-/- or Slamf5-/- CD4+ T cells caused the same pathology as WT CD4+ T cells. As the transfer of Slamf [1+6]-/- or Slamf [1+5+6]-/- CD4+ T cells induced WT levels of autoantibodies, the presence of Slamf1 was requisite for the induction of increased levels of autoantibodies by Slamf6-/- CD4+ T cells. We conclude that Slamf6 functions as an inhibitory receptor that controls autoimmune responses. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.clim.2016.06.009 | - |
dc.relation.ispartof | Clinical Immunology, 2016, vol. 173, p. 19-26 | - |
dc.relation.uri | https://doi.org/10.1016/j.clim.2016.06.009 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.other | Autoimmune diseases | - |
dc.subject.other | T cells | - |
dc.title | Slamf6 negatively regulates autoimmunity | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 667634 | - |
dc.date.updated | 2019-02-08T15:30:18Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27368806 | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
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667634.pdf | 1.14 MB | Adobe PDF | View/Open |
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