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Title: Hydrogen Atom Transfer (HAT)-Triggered Iron-Catalyzed Intra- and Intermolecular Coupling of Alkenes with Hydrazones: Access to Complex Amines
Author: Saladrigas, Mar
Loren, Guillem
Bonjoch i Sesé, Josep
Bradshaw, Ben
Keywords: Amines
Enllaços químics
Química orgànica
Chemical bonds
Organic chemistry
Issue Date: Nov-2018
Publisher: American Chemical Society
Abstract: A methodology for the coupling of alkenes with aldehyde- or ketone-derived Cbz-hydrazones to form a new C−C bond through a radical process is described. The sequence comprises an initial in situ generation of a putative iron hydride followed by a hydrogen atom transfer to an alkene, a coupling with a hydrazone, and a final reduction of the nitrogen-centered radical. Hydrogenation of the obtained hydrazines renders amines, including valuable tert-alkyl amines. KEYWORDS: HAT, iron catalysis, α-tert-amines, C−C bond formation, radical processes, synthetic methods
Note: Versió postprint del document publicat a:
It is part of: ACS Catalysis, 2018, vol. 8, p. 11699-11703
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ISSN: 2155-5435
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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