Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/130635
Title: Epigenetic outlier profiles in depression. A genome-wide DNA Methylation analysis of MZ twins
Author: Córdova Palomera, Aldo
Palma Gudiel, Helena
Fores Martos, Jaume
Tabares Seisdedos, Rafael
Fañanás Saura, Lourdes
Keywords: Epigenètica
Bessons
Depressió psíquica
Expressió gènica
Epigenetics
Twins
Mental depression
Gene expression
Issue Date: 20-Nov-2018
Publisher: Public Library of Science (PLoS)
Abstract: Recent discoveries highlight the importance of stochastic epigenetic changes, as indexed by epigenetic outlier DNA methylation signatures, as a valuable tool to understand aberrant cell function and subsequent human pathology. There is evidence of such changes in different complex disorders as diverse as cancer, obesity and, to a lesser extent, depression. The current study was aimed at identifying outlying DNA methylation signatures of depressive psychopathology. Here, genome-wide DNA methylation levels were measured (by means of Illumina Infinium HumanMethylation450 Beadchip) in peripheral blood of thirty-four monozygotic twins informative for depressive psychopathology (lifetime DSM-IV diagnoses). This dataset was explored to identify outlying epigenetic signatures of depression, operationalized as extreme hyper- or hypo-methylation in affected co-twins from discordant pairs that is not observed across the rest of the study sample. After adjusting for blood cell count, there were thirteen CpG sites across which depressed co-twins from the discordant pairs exhibited outlying DNA methylation signatures. None of them exhibited a methylation outlier profile in the concordant and healthy pairs, and some of these loci spanned genes previously associated with neuropsychiatric phenotypes, such as GHSR and KCNQ1. This exploratory study provides preliminary proof-of-concept validation that epigenetic outlier profiles derived from genome-wide DNA methylation data may be related to depression risk.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0207754
It is part of: PLoS One, 2018, vol. 13 , num. 11, p. e0207754
URI: http://hdl.handle.net/2445/130635
Related resource: https://doi.org/10.1371/journal.pone.0207754
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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