Please use this identifier to cite or link to this item:
Title: Enhancement of immune maturation in suckling rats by leptin and adiponectin supplementation
Author: Grases Pintó, Blanca
Abril Gil, Maria del Mar
Castell, Margarida
Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
Keywords: Llet materna
Sistema immunològic
Breast milk
Immune system
Issue Date: 11-Feb-2019
Publisher: Nature Publishing Group
Abstract: Leptin and adiponectin, adipokines present in breast milk, have shown immunomodulatory properties. The current study aimed to ascertain whether a nutritional supplementation with leptin or adiponectin in neonatal rats was able to infuence the maturation of the systemic immune response in early life. To achieve this, suckling Wistar rats were supplemented with either leptin (0.7μg/kg/day) or adiponectin (35μg/kg/day) during the whole suckling period. Plasmatic immunoglobulins were quantifed, and spleen lymphocyte composition and their ability to proliferate and release cytokines were evaluated during (day 14) and at the end (day 21) of the suckling period. Rats fed with either adipokine showed higher plasma IgM and IgG1 concentrations and adiponectin supplementation also increased IgG2a at both studied days (P<0.05). With regard to the lymphocyte composition, both adipokine supplementations increased T cell proportion and both CD4+ and CD8+ T cell subsets after two weeks of supplementation (P<0.05). Moreover, only leptin administration increased NK and NKT cell proportions at the end of the suckling period. Finally, both adipokines infuenced the cytokine secretion pattern by splenocytes. In conclusion, these results suggest that leptin and adiponectin play a role in the maturation of the systemic immune response during the suckling period.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2019, vol. 9, p. 1786
Related resource:
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

Files in This Item:
File Description SizeFormat 
686430.pdf1.44 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons