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Title: Cannabis use in male and female first episode of non-affective psychosis patients: long-term clinical, neuropsychological and functional differences
Author: Setien Suero, Esther
Neergaard, Karl
Ramirez Bonilla, Mariluz
Correa Ghisays, Patricia
Fañanás Saura, Lourdes
Crepo Facorro, Benedicto
Ayesa Arriola, Rosa
Keywords: Cànnabis
Factors sexuals en les malalties
Sex factors in disease
Issue Date: 23-Aug-2017
Publisher: Public Library of Science (PLoS)
Abstract: BACKGROUND: Numerous studies show the existence of a high prevalence of cannabis use among patients with psychosis. However, the differences between men and women who debut with a first episode of psychosis (FEP) regarding cannabis use have not been largely explored. The aim of this study was to identify the specific sex factors and differences in clinical evolution associated with cannabis use. METHOD: Sociodemographic characteristics at baseline were considered in our sample of FEP patients to find differences depending on sex and the use of cannabis. Clinical, functional and neurocognitive variables at baseline, 1-year, and 3-years follow-up were also explored. RESULTS: A total of 549 patients, of whom 43% (N = 236) were cannabis users, 79% (N = 186) male and 21% (N = 50) female, were included in the study. There was a clear relationship between being male and being a user of cannabis (OR = 5.6). Cannabis users were younger at illness onset. Longitudinal analysis showed that women significantly improved in all three dimensions of psychotic symptoms, both in the subgroup of cannabis users and in the non-users subgroup. Conversely, subgroups of men did not show improvement in the negative dimension. In cognitive function, only men presented a significant time by group interaction in processing speed, showing a greater improvement in the subgroup of cannabis users. CONCLUSION: Despite knowing that there is a relationship between cannabis use and psychosis, due to the high prevalence of cannabis use among male FEP patients, the results showed that there were very few differences in clinical and neurocognitive outcomes between men and women who used cannabis at the start of treatment compared to those who did not.
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It is part of: PLoS One, 2017, vol. 12, num. 8, p. e0183613
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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