Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/13275
Title: | Viral self-assembly as a thermodynamic process |
Author: | Bruinsma, Robijn F. Gelbart, William M. Reguera, D. (David) Rudnick, Joseph Zandi, Roya |
Keywords: | Biofísica Ciència dels materials Termodinàmica estadística Biological and medical physics Materials science Statistical thermodynamics |
Issue Date: | 2003 |
Publisher: | American Physical Society |
Abstract: | The protein shells, or capsids, of nearly all spherelike viruses adopt icosahedral symmetry. In the present Letter, we propose a statistical thermodynamic model for viral self-assembly. We find that icosahedral symmetry is not expected for viral capsids constructed from structurally identical protein subunits and that this symmetry requires (at least) two internal switching configurations of the protein. Our results indicate that icosahedral symmetry is not a generic consequence of free energy minimization but requires optimization of internal structural parameters of the capsid proteins |
Note: | Reproducció digital del document proporcionada per PROLA i http://dx.doi.org/10.1103/PhysRevLett.90.248101 |
It is part of: | Physical Review Letters, 2003, vol. 90, núm. 24, p. 248101-1-248101-4 |
URI: | http://hdl.handle.net/2445/13275 |
Related resource: | http://dx.doi.org/10.1103/PhysRevLett.90.248101 |
ISSN: | 0031-9007 |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
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