Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/13275
Title: Viral self-assembly as a thermodynamic process
Author: Bruinsma, Robijn F.
Gelbart, William M.
Reguera, D. (David)
Rudnick, Joseph
Zandi, Roya
Keywords: Biofísica
Ciència dels materials
Termodinàmica estadística
Biological and medical physics
Materials science
Statistical thermodynamics
Issue Date: 2003
Publisher: American Physical Society
Abstract: The protein shells, or capsids, of nearly all spherelike viruses adopt icosahedral symmetry. In the present Letter, we propose a statistical thermodynamic model for viral self-assembly. We find that icosahedral symmetry is not expected for viral capsids constructed from structurally identical protein subunits and that this symmetry requires (at least) two internal switching configurations of the protein. Our results indicate that icosahedral symmetry is not a generic consequence of free energy minimization but requires optimization of internal structural parameters of the capsid proteins
Note: Reproducció digital del document proporcionada per PROLA i http://dx.doi.org/10.1103/PhysRevLett.90.248101
It is part of: Physical Review Letters, 2003, vol. 90, núm. 24, p. 248101-1-248101-4
URI: http://hdl.handle.net/2445/13275
ISSN: 0031-9007
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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