Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/133151
Title: Wnt evolution and function shuffling in liberal and conservative chordate genomes
Author: Somorjai, Ildikó M. L.
Martí Solans, Josep
Diaz Gracia, Miriam
Nishida, Hiroki
Imai, Kaoru S.
Escrivà, Hector
Cañestro García, CristianCañestro García, Cristian
Albalat Rodríguez, Ricard
Keywords: Proteïnes
Genòmica
Proteins
Genomics
Issue Date: 25-Jul-2018
Publisher: BioMed Central
Abstract: Background What impact gene loss has on the evolution of developmental processes, and how function shuffling has affected retained genes driving essential biological processes, remain open questions in the fields of genome evolution and EvoDevo. To investigate these problems, we have analyzed the evolution of the Wnt ligand repertoire in the chordate phylum as a case study. Results We conduct an exhaustive survey of Wnt genes in genomic databases, identifying 156 Wnt genes in 13 non-vertebrate chordates. This represents the most complete Wnt gene catalog of the chordate subphyla and has allowed us to resolve previous ambiguities about the orthology of many Wnt genes, including the identification of WntA for the first time in chordates. Moreover, we create the first complete expression atlas for the Wnt family during amphioxus development, providing a useful resource to investigate the evolution of Wnt expression throughout the radiation of chordates. Conclusions Our data underscore extraordinary genomic stasis in cephalochordates, which contrasts with the liberal and dynamic evolutionary patterns of gene loss and duplication in urochordate genomes. Our analysis has allowed us to infer ancestral Wnt functions shared among all chordates, several cases of function shuffling among Wnt paralogs, as well as unique expression domains for Wnt genes that likely reflect functional innovations in each chordate lineage. Finally, we propose a potential relationship between the evolution of WntA and the evolution of the mouth in chordates.
Note: Reproducció del document publicat a: https://doi.org/10.1186/s13059-018-1468-3
It is part of: Genome Biology, 2018, vol. 19, p. 98
URI: http://hdl.handle.net/2445/133151
Related resource: https://doi.org/10.1186/s13059-018-1468-3
ISSN: 1474-7596
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Institut de Recerca de la Biodiversitat (IRBio))

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