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Title: MOG encephalomyelitis: international recommendations on diagnosis and antibody testing
Author: Jarius, S.
Paul, F.
Aktas, Orhan
Asgari, Nasrin
Dale, Russell C.
Seze, J. de
Franciotta, Diego
Fujihara, Kazuo
Jacob, Anu
Kim, H. J.
Kleiter, Ingo
Kümpfel, Tania
Levy, Michael
Palace, Jacqueline
Ruprecht, Klemens
Saiz Hinajeros, Albert
Trebst, Corinna
Weinshenker, Brian G.
Wildemann, Brigitte
Keywords: Diagnòstic
Esclerosi múltiple
Malalties del sistema nerviós central
Multiple sclerosis
Central nervous system diseases
Issue Date: 3-May-2018
Publisher: BioMed Central
Abstract: Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, myelitis and brainstem encephalitis, as well as with acute disseminated encephalomyelitis (ADEM)-like presentations. Most experts now consider MOG-IgG-associated encephalomyelitis (MOG-EM) a disease entity in its own right, immunopathogenetically distinct from both classic multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG-positive neuromyelitis optica spectrum disorders (NMOSD). Owing to a substantial overlap in clinicoradiological presentation, MOG-EM was often unwittingly misdiagnosed as MS in the past. Accordingly, increasing numbers of patients with suspected or established MS are currently being tested for MOG-IgG. However, screening of large unselected cohorts for rare biomarkers can significantly reduce the positive predictive value of a test. To lessen the hazard of overdiagnosing MOG-EM, which may lead to inappropriate treatment, more selective criteria for MOG-IgG testing are urgently needed. In this paper, we propose indications for MOG-IgG testing based on expert consensus. In addition, we give a list of conditions atypical for MOG-EM ('red flags') that should prompt physicians to challenge a positive MOG-IgG test result. Finally, we provide recommendations regarding assay methodology, specimen sampling and data interpretation.
Note: Reproducció del document publicat a:
It is part of: Journal of Neuroinflammation, 2018, vol. 15, num. 1
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ISSN: 1742-2094
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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